Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Indian J Dermatol Venereol Leprol. 2021 May-Jun;87(3):341-347. doi: 10.25259/IJDVL_877_19.
Lichen planus pigmentosus can have a negative impact on the quality of life; however, this has not been studied in detail.
To study the quality of life in patients with lichen planus pigmentosus and compare it with patients with vitiligo and melasma.
This was a cross-sectional study conducted in a tertiary-care center in north India from January 2018 to May 2019. Patients ≥ 18 years of age with lichen planus pigmentosus (n = 125), vitiligo (n = 113) and melasma (n = 121) completed the Dermatology Life Quality Index (DLQI) questionnaire and answered a global question on the effect of disease on their lives. In addition, patients with vitiligo completed the Vitiligo Impact Scale (VIS)-22 questionnaire, while those with lichen planus pigmentosus and melasma filled a modified version of VIS-22.
The mean DLQI scores in patients with lichen planus pigmentosus, vitiligo and melasma were 10.9 ± 5.95, 9.73 ± 6.51 and 8.39 ± 5.92, respectively, the difference being statistically significant only between lichen planus pigmentosus and melasma (P < 0.001). The corresponding mean modified VIS-22/VIS-22 scores were 26.82 ± 11.89, 25.82 ± 14.03 and 18.87 ± 11.84, respectively. This difference was statistically significant between lichen planus pigmentosus and melasma, and between vitiligo and melasma (P < 0.001 for both). As compared to vitiligo, patients with lichen planus pigmentosus had a significantly greater impact on "symptoms and feelings" domain (P < 0.001) on DLQI, and on "social interactions" (P = 0.02) and "depression" (P = 0.04) domains on VIS-22. As compared to melasma, patients with lichen planus pigmentosus had significantly higher scores for "symptoms and feelings," "daily activities," "leisure" and "work and school" domains of DLQI, and all domains of VIS-22. Female gender was more associated with impairment in quality of life in patients with lichen planus pigmentosus, while lower education, marriage, younger age and increasing disease duration showed a directional trend.
Use of DLQI and modified version of VIS-22 scales in the absence of a pigmentary disease-specific quality-of-life instrument.
Patients with lichen planus pigmentosus have a significantly impaired quality of life. The psychosocial burden of lichen planus pigmentosus is quantitatively similar to that of vitiligo, but significantly greater than melasma.
色素性扁平苔藓可能会对生活质量产生负面影响，但目前尚未对此进行详细研究。
研究色素性扁平苔藓患者的生活质量，并将其与白癜风和黄褐斑患者进行比较。
这是一项在印度北部一家三级保健中心进行的横断面研究，时间为 2018 年 1 月至 2019 年 5 月。年龄≥ 18 岁的色素性扁平苔藓（n = 125）、白癜风（n = 113）和黄褐斑（n = 121）患者完成皮肤病生活质量指数（DLQI）问卷，并回答了一个关于疾病对生活影响的总体问题。此外，白癜风患者完成了白癜风影响量表（VIS）-22 问卷，而色素性扁平苔藓和黄褐斑患者则填写了改良的 VIS-22 问卷。
色素性扁平苔藓、白癜风和黄褐斑患者的平均 DLQI 评分分别为 10.9 ± 5.95、9.73 ± 6.51 和 8.39 ± 5.92，差异仅在色素性扁平苔藓和黄褐斑之间具有统计学意义（P < 0.001）。相应的平均改良 VIS-22/VIS-22 评分分别为 26.82 ± 11.89、25.82 ± 14.03 和 18.87 ± 11.84。色素性扁平苔藓和黄褐斑之间，以及白癜风和黄褐斑之间的差异均具有统计学意义（均 P < 0.001）。与白癜风相比，色素性扁平苔藓患者在 DLQI 的“症状和感受”（P < 0.001）以及 VIS-22 的“社会互动”（P = 0.02）和“抑郁”（P = 0.04）领域的影响更大。与黄褐斑相比，色素性扁平苔藓患者在 DLQI 的“症状和感受”、“日常活动”、“休闲”和“工作和学校”领域以及 VIS-22 的所有领域的评分均更高。女性在色素性扁平苔藓患者的生活质量受损中更为相关，而较低的教育程度、婚姻状况、年轻的年龄和较长的疾病持续时间则显示出一种趋势。
在缺乏色素性疾病特异性生活质量工具的情况下，使用 DLQI 和改良的 VIS-22 量表。
色素性扁平苔藓患者的生活质量显著受损。色素性扁平苔藓的心理社会负担与白癜风相当，但明显大于黄褐斑。
