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可吸收的纯化猪皮明胶与戊二醛交联微球用于颈动脉体副神经节瘤的术前栓塞。

Resorbable Purified Porcine Skin Gelatin Cross-Linked with Glutaraldehyde Spheres for Preoperative Embolization of Carotid Body Paraganglioma.

机构信息

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.

Fondazione IRCCS ospedale Maggiore Policlinico Milano.

出版信息

Acta Biomed. 2021 Apr 30;92(S1):e2021159. doi: 10.23750/abm.v92iS1.9488.

DOI:10.23750/abm.v92iS1.9488
PMID:33944842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8142762/
Abstract

Chemodectomas are rare neuroendocrine tumors that typically arise at the carotid bifurcation and progressively englobe the internal and external carotid artery. Surgical asportation of the capsulated mass is the elective treatment. Pre-procedural embolization of this high vascular tumors is highly recommended because it has shown to improve surgical outcome by reducing both, mean blood loss and total operation time. Many different embolization techniques have been described in literature. In the here presented case we opted for an endovascular approach using resorbable purified porcine skin gelatin cross-linked with glutaraldehyde microspheres (Optisphere - MEDTRONIC) as an embolic agent. These turned out to be very safe and effective in improving surgical outcome by reducing operative blood loss and thus reducing treatment-related morbidity.

摘要

化学感受器瘤是一种罕见的神经内分泌肿瘤,通常发生在颈动脉分叉处,并逐渐包围颈内动脉和颈外动脉。手术切除囊状肿块是首选的治疗方法。由于术前栓塞这种高血管肿瘤可以减少术中平均失血量和总手术时间,因此强烈推荐这种治疗方法。文献中已经描述了许多不同的栓塞技术。在本病例中,我们选择了一种使用可吸收的纯化猪皮明胶交联戊二醛微球(Optisphere - MEDTRONIC)作为栓塞剂的血管内方法。这些方法在减少手术相关发病率方面通过减少手术失血量来改善手术结果,非常安全有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/8142762/e62b3fc14e44/ACTA-92-159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/8142762/38934524fb1f/ACTA-92-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/8142762/e62b3fc14e44/ACTA-92-159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/8142762/38934524fb1f/ACTA-92-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/8142762/e62b3fc14e44/ACTA-92-159-g002.jpg

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Resorbable Purified Porcine Skin Gelatin Cross-Linked with Glutaraldehyde Spheres for Preoperative Embolization of Carotid Body Paraganglioma.可吸收的纯化猪皮明胶与戊二醛交联微球用于颈动脉体副神经节瘤的术前栓塞。
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本文引用的文献

1
Update in the classification and the role of intra-arterial stenting in the management of carotid body paragangliomas.颈动脉体副神经节瘤的分类和动脉内支架置入治疗的更新。
Head Neck. 2019 May;41(5):1379-1386. doi: 10.1002/hed.25567. Epub 2019 Feb 16.
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Multi-institutional survey of carotid body tumors in Japan.日本颈动脉体瘤的多机构调查。
Oncol Lett. 2018 Apr;15(4):5318-5324. doi: 10.3892/ol.2018.7925. Epub 2018 Feb 2.
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Current approaches and recent developments in the management of head and neck paragangliomas.头颈部副神经节瘤治疗的当前方法与最新进展
Endocr Rev. 2014 Oct;35(5):795-819. doi: 10.1210/er.2014-1026. Epub 2014 Jul 17.
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Impact of preoperative embolization on outcomes of carotid body tumor resections.术前栓塞对颈动脉体瘤切除术结果的影响。
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Head, neck, and brain tumor embolization guidelines.头颈部和脑肿瘤栓塞治疗指南。
J Neurointerv Surg. 2012 Jul;4(4):251-5. doi: 10.1136/neurintsurg-2012-010350. Epub 2012 Apr 26.
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Endovascular embolization of paragangliomas: A safe adjuvant to treatment.副神经节瘤的血管内栓塞术:一种安全的治疗辅助手段。
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Percutaneous embolization of carotid paragangliomas using solely Onyx.仅使用Onyx对颈动脉体瘤进行经皮栓塞术。
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Temporary balloon occlusion and ethanol injection for preoperative embolization of carotid-body tumor.临时球囊闭塞和乙醇注射用于颈动脉体瘤术前栓塞
Ear Nose Throat J. 2002 Aug;81(8):536-8, 540, 542 passim.