Wanke I, Jäckel M C, Goericke S, Panagiotopoulos V, Dietrich U, Forsting M
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University of Essen, Hufelandstrasse 55, Essen, Germany.
AJNR Am J Neuroradiol. 2009 Sep;30(8):1594-7. doi: 10.3174/ajnr.A1601. Epub 2009 Apr 15.
Paragangliomas are highly vascularized usually benign neoplasms arising from nerve tissue. Endovascular preoperative embolization is used to facilitate surgery but is often not complete, due to tiny feeding arteries not feasible for selective catheterization. Our purpose was to evaluate angiographic and clinical outcome using Onyx for percutaneous glomus tumor embolization.
A consecutive series of 4 patients with 6 paragangliomas located at the bifurcation of the common carotid artery were treated with percutaneous embolization using Onyx as the sole embolic material.
Complete devascularization of the 6 paragangliomas was achieved using a percutaneous embolization technique with Onyx as a sole agent, combined with an endovascular microballoon that offered protection of the internal carotid artery.
Further documentation is necessary to prove the higher grade of devascularization of paragangliomas with Onyx compared with other embolic material and the associated potential to facilitate surgery. Nevertheless, Onyx seems to be safe when used percutaneously due to its lavalike pattern flow and its controllable properties, allowing slow tumor bed penetration.
副神经节瘤是起源于神经组织的高度血管化的通常为良性的肿瘤。血管内术前栓塞用于辅助手术,但由于存在难以进行选择性插管的微小供血动脉,栓塞往往不彻底。我们的目的是评估使用Onyx进行经皮球瘤栓塞的血管造影和临床结果。
连续4例共6个位于颈总动脉分叉处的副神经节瘤患者接受了以Onyx作为唯一栓塞材料的经皮栓塞治疗。
采用以Onyx作为唯一药物的经皮栓塞技术,结合可保护颈内动脉的血管内微球囊,实现了6个副神经节瘤的完全去血管化。
需要进一步的文献来证明与其他栓塞材料相比,Onyx使副神经节瘤去血管化的程度更高以及其辅助手术的相关潜力。然而,由于Onyx呈熔岩样流动模式且具有可控性,允许其缓慢渗透至肿瘤床,经皮使用时似乎是安全的。