University of Vermont Larner College of Medicine, Burlington, Vermont.
University of Vermont Larner College of Medicine, Burlington, Vermont.
Ann Thorac Surg. 2022 Apr;113(4):1159-1164. doi: 10.1016/j.athoracsur.2021.04.046. Epub 2021 May 1.
Because of the limited published information on complications that obstructive sleep apnea (OSA) patients experience during and after cardiac surgery, we investigated OSA as a risk factor for postoperative outcomes.
This project used the Northern New England Cardiovascular Disease Study Group's data collected between 2011 and 2017 based on The Society of Thoracic Surgeons Adult Cardiac Surgery Database Data Collections form. A retrospective analysis of 1555 patients with OSA and 10,450 patients without OSA across 5 medical centers undergoing isolated coronary artery bypass grafting, isolated valve surgery, and combined coronary artery bypass grafting valve surgery was conducted. We used 1:1 nearest-neighbor propensity score matching with no replacement to balance characteristics among patients with and without OSA.
There was a statistically significant increased risk of postoperative pneumonia, increased length of total and postoperative stay, and time to initial extubation. Two outcomes trended toward significance: intra- and postoperative intraaortic balloon pump use. Outcomes that failed to show statistical significance were surgical site infection, atrial fibrillation, cerebrovascular accident, permanent pacemaker placement, and blood products given. A chart review conducted on a subset of the study cohort revealed that more than 40% of OSA patients did not receive continuous positive airway pressure or bilevel positive airway pressure therapy postoperatively during their hospitalization.
Our study aligns with the literature in concluding that OSA has deleterious effects on postoperative outcomes of cardiac surgery patients. Further research to better stratify OSA patients by severity are still needed. Additionally heightened awareness of the need to screen, diagnose, and properly treat patients for OSA is needed.
由于阻塞性睡眠呼吸暂停(OSA)患者在心脏手术后期间和之后经历的并发症的相关信息有限,我们研究了 OSA 作为术后结果的一个风险因素。
本项目使用了北方新英格兰心血管疾病研究小组在 2011 年至 2017 年期间基于胸外科医师学会成人心脏手术数据库数据收集表收集的数据。对 5 家医疗中心的 1555 例 OSA 患者和 10450 例无 OSA 患者进行了回顾性分析,这些患者接受了单纯冠状动脉旁路移植术、单纯瓣膜手术和冠状动脉旁路移植术联合瓣膜手术。我们使用了 1:1 最近邻倾向评分匹配(无替换)来平衡 OSA 患者和无 OSA 患者的特征。
术后肺炎、总住院时间和术后住院时间以及首次拔管时间的风险显著增加。两种结果呈显著趋势:术中及术后主动脉内球囊泵使用。手术部位感染、心房颤动、脑血管意外、永久性起搏器植入和血液制品使用等结果未显示统计学意义。对研究队列的一部分进行了图表审查,结果发现,超过 40%的 OSA 患者在住院期间术后没有接受持续气道正压通气或双水平气道正压通气治疗。
我们的研究与文献一致,即 OSA 对心脏手术患者的术后结果有不良影响。仍然需要进一步研究以更好地对 OSA 患者进行严重程度分层。此外,需要提高对筛查、诊断和正确治疗 OSA 患者的必要性的认识。