Fontanals N, Zohar J, Borrull F, Ronka S, Marcé R M
Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Marcel•lí Domingo, 1, Campus Sescelades, 43007 Tarragona, Spain.
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.
J Chromatogr A. 2021 Jun 21;1647:462165. doi: 10.1016/j.chroma.2021.462165. Epub 2021 Apr 21.
This study presents a novel mixed-mode weak cation-exchange (WCX) material. This material was prepared by means of the functionalization of a mesoporous divinylbenzene (DVB) resin with maleic acid (maleic acid-DVB), which yielded a high carboxylic moiety content resulting in WCX interactions as well as suitable specific surface area for reversed-phase interactions. After the optimization of the solid-phase extraction (SPE) protocol to enhance the selectivity of the sorbent, this material was evaluated as a novel WCX sorbent in the SPE of a group of drugs from environmental water samples. The method is based on SPE followed by liquid chromatography (LC) coupled to high resolution mass spectrometry (HRMS) with an Orbitrap analyzer, and was validated and applied for the determination of basic drugs in river, effluent and influent wastewater samples. Maleic acid-DVB sorbent yielded suitable recovery rates (57% to 89%) and an acceptable matrix effect (<32%) thanks to the effective washing step included when these environmental waters were loaded through the novel resin. The method was applied to different environmental water samples and some basic drugs were suitably quantified in these environmental samples.
本研究提出了一种新型的混合模式弱阳离子交换（WCX）材料。该材料是通过用马来酸（马来酸 - 二乙烯基苯）对介孔二乙烯基苯（DVB）树脂进行功能化制备而成，其产生了高含量的羧基部分，从而实现WCX相互作用以及适合反相相互作用的比表面积。在优化固相萃取（SPE）方案以提高吸附剂的选择性之后，该材料被评估为一种新型的WCX吸附剂，用于从环境水样中萃取一组药物。该方法基于SPE，随后是液相色谱（LC）与配备Orbitrap分析仪的高分辨率质谱（HRMS）联用，并经过验证后应用于测定河流、污水和进水废水样品中的碱性药物。由于在这些环境水样通过新型树脂加载时包含有效的洗涤步骤，马来酸 - DVB吸附剂产生了合适的回收率（57%至89%）和可接受的基质效应（<32%）。该方法应用于不同的环境水样，并且在这些环境样品中对一些碱性药物进行了适当的定量分析。
