Levy D, Kannel W B
Cardiology Laboratory, Framingham Heart Study, MA 01701.
Am Heart J. 1988 Jul;116(1 Pt 2):266-72. doi: 10.1016/0002-8703(88)90099-3.
Although cardiovascular disease remains the leading cause of death in the United States, its incidence has decreased steadily during the past 20 years. This trend is largely attributable to improved detection and management of cardiovascular risk factors. The pioneering work of the Framingham Heart Study, which has followed subjects since the late 1940s, has helped shed light on the risks conferred by factors such as advancing age, hypertension, smoking, elevated serum cholesterol, diabetes, left ventricular hypertrophy, and obesity. As a result of this ongoing investigation, clinicians have gained a better understanding of the ways in which cardiovascular risks can be modified so that mortality rates will hopefully continue to decline.
尽管心血管疾病仍是美国的主要死因，但其发病率在过去20年中稳步下降。这一趋势很大程度上归因于心血管危险因素检测和管理的改善。自20世纪40年代末以来一直跟踪研究对象的弗雷明汉心脏研究的开创性工作，有助于揭示诸如年龄增长、高血压、吸烟、血清胆固醇升高、糖尿病、左心室肥厚和肥胖等因素所带来的风险。由于这项持续进行的调查，临床医生对可以改变心血管风险的方式有了更好的理解，从而有望使死亡率继续下降。
