Youn Young-Ah, Shin Seung-Han, Kim Ee-Kyung, Jin Hye-Jeong, Jung Young-Hwa, Heo Ju-Sun, Jeon Ji-Hyun, Park Joo-Hyun, Sung In-Kyung
Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Pediatrics, Seoul National University Children's Hospital, Seoul 03080, Korea.
Brain Sci. 2021 Apr 29;11(5):575. doi: 10.3390/brainsci11050575.
Increased survival in the very preterm population results in a higher risk of developing neurodevelopmental and behavioral disabilities among survivors. We examined the outcomes of very preterm infants and parents after a preventive intervention program of four home visits by a specialized nurse, 5 days, 2 weeks, and 1 month after discharge, respectively, and at CA 2 months, followed by up to 12 times of group sessions between CA 3 and 6 months. Our multicenter randomized controlled trial assessed 138 preterm infants (gestational age ≤30 weeks or birth weight ≤1500 g) enrolled from the three participating hospitals. We randomly allocated the preterm babies to either the intervention or the control group. The primary outcome was the neurodevelopmental outcomes of Bayley-III scores at CA 10 and 24 months. At CA 10 months and 24 months, there were no significant differences between the intervention and control groups in the cognitive, motor, and language domains of Bayley-III scores. In addition, there were no significant differences in the mother's depression scale, mother-child attachment, and the modified Infant and Toddler Social and Emotional Assessment.
极早产儿存活率的提高导致幸存者出现神经发育和行为障碍的风险增加。我们对极早产儿及其父母在一项预防性干预项目后的结局进行了研究，该项目包括由一名专业护士分别在出院后5天、2周和1个月以及实际年龄2个月时进行4次家访，随后在实际年龄3至6个月期间进行多达12次小组会议。我们的多中心随机对照试验评估了从三家参与医院招募的138名早产儿（胎龄≤30周或出生体重≤1500克）。我们将这些早产儿随机分配到干预组或对照组。主要结局是实际年龄10个月和24个月时贝利婴幼儿发展量表第三版（Bayley-III）评分的神经发育结局。在实际年龄10个月和24个月时，干预组和对照组在Bayley-III评分的认知、运动和语言领域没有显著差异。此外，在母亲抑郁量表、母婴依恋以及改良的婴幼儿社会和情感评估方面也没有显著差异。
