Brinkmann Max Philipp, Kibele Nikolas Xavier, Prasuhn Michelle, Kakkassery Vinodh, Toro Mario Damiano, Ranjbar Mahdy, Grisanti Salvatore, Becker Matthias, Rommel Felix
Department of Ophthalmology, Stadtspital Waid und Triemli Zürich, 8063 Zürich, Switzerland.
Department of Ophthalmology, Klinikum Klagenfurt, A-9020 Klagenfurt, Austria.
Diagnostics (Basel). 2021 Apr 29;11(5):808. doi: 10.3390/diagnostics11050808.
Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal perfusion state in vivo. This study aimed to evaluate the acute effects of isometric and dynamic exercise on retinal and choroidal sublayer perfusion using OCTA. A pilot study was conducted on young, healthy participants, each of whom performed a specific isometric exercise on the first day and a dynamic exercise the day after. At baseline and immediately after the exercise, heart rate (HR), mean arterial pressure (MAP), superficial capillary plexus perfusion (SCPP), deep capillary plexus perfusion (DCPP), choriocapillaris perfusion (CCP), Sattlers's layer perfusion (SLP), and Haller's layer perfusion (HLP) were recorded. A total of 34 eyes of 34 subjects with a mean age of 32.35 ± 7.87 years were included. HR as well as MAP increased significantly after both types of exercise. Both SCPP and DCPP did not show any significant alteration due to isometric or dynamic exercise. After performing dynamic exercise, CCP, SLP, as well as HLP significantly increased. Changes in MAP correlated significantly with changes in HLP after the dynamic activity. OCTA-based analysis in healthy adults following physical activity demonstrated a constant retinal perfusion, supporting the theory of autoregulatory mechanisms. Dynamic exercise, as opposed to isometric activity, significantly changed choroidal perfusion. OCTA imaging may represent a novel and sensitive tool to expand the diagnostic spectrum in the field of sports medicine.
光学相干断层扫描血管造影（OCTA）是一种用于在体内成像和量化视网膜及脉络膜灌注状态的非侵入性工具。本研究旨在使用OCTA评估等长运动和动态运动对视网膜及脉络膜各层灌注的急性影响。对年轻健康的参与者进行了一项初步研究，每位参与者在第一天进行特定的等长运动，第二天进行动态运动。在基线和运动后立即记录心率（HR）、平均动脉压（MAP）、浅表毛细血管丛灌注（SCPP）、深层毛细血管丛灌注（DCPP）、脉络膜毛细血管灌注（CCP）、萨特勒层灌注（SLP）和哈勒层灌注（HLP）。共纳入34名受试者的34只眼，平均年龄为32.35±7.87岁。两种运动后HR和MAP均显著升高。等长运动或动态运动后，SCPP和DCPP均未显示出任何显著变化。进行动态运动后，CCP、SLP和HLP显著增加。动态活动后，MAP的变化与HLP的变化显著相关。基于OCTA对健康成年人进行体育活动后的分析表明视网膜灌注恒定，支持了自动调节机制的理论。与等长运动相反，动态运动显著改变了脉络膜灌注。OCTA成像可能是一种新颖且敏感的工具，可扩大运动医学领域的诊断范围。
