Alderman B W, Lammer E J, Joshua S C, Cordero J F, Ouimette D R, Wilson M J, Ferguson S W
Department of Preventive Medicine and Biometrics, University of Colorado Medical School, Denver 80262.
Am J Epidemiol. 1988 Aug;128(2):431-8. doi: 10.1093/oxfordjournals.aje.a114983.
This population-based case-control study was designed to investigate risk indicators for the occurrence of the birth defect craniosynostosis in Colorado. A total of 173 children who underwent craniectomy for craniosynostosis and 759 children without craniosynostosis were included in the study. Multivariable logistic regression analysis of birth certificate data showed that male sex (odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.1-2.2), maternal five-year age "increase" (OR = 1.3, 95% CI = 1.1-1.5), plural birth (OR = 3.0, 95% CI = 1.2-7.1) and black maternal race (OR = 0.0, 95 per cent CI = 0.0-0.6) were independently associated with craniosynostosis. There was a weak positive association between craniosynostosis and the altitude of the town closest to the maternal residence, but no association was found with maternal education, marital status, number of previous births, or previous pregnancy termination. The association of craniosynostosis with plural birth is consistent with the hypothesis of fetal head constraint.
这项基于人群的病例对照研究旨在调查科罗拉多州颅缝早闭这种出生缺陷发生的风险指标。该研究共纳入了173名因颅缝早闭接受颅骨切除术的儿童和759名无颅缝早闭的儿童。对出生证明数据进行多变量逻辑回归分析显示，男性（比值比（OR）=1.6，95%置信区间（CI）=1.1 - 2.2）、母亲年龄五年“增长”（OR = 1.3，95% CI = 1.1 - 1.5）、多胞胎（OR = 3.0，95% CI = 1.2 - 7.1）以及黑人母亲种族（OR = 0.0，95% CI = 0.0 - 0.6）与颅缝早闭独立相关。颅缝早闭与最接近母亲居住地城镇的海拔之间存在微弱的正相关，但未发现与母亲教育程度、婚姻状况、既往生育次数或既往终止妊娠存在关联。颅缝早闭与多胞胎的关联与胎儿头部受限假说一致。
