Corwin H L, Schwartz M M, Lewis E J
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill.
Am J Nephrol. 1988;8(2):85-9. doi: 10.1159/000167563.
The number of abnormal glomeruli present in a renal biopsy can be viewed as a binomial distribution. Recognition of this fact permits a quantitative assessment of the effect of biopsy sample size in renal biopsy interpretation. If the percent of glomerular involvement in a biopsy is used to determine the severity of a focal glomerular lesion, a small biopsy sample size will lead to considerable misclassification of disease severity. In addition, a small biopsy sample size will make the exclusion of focal disease difficult.
肾活检中出现的异常肾小球数量可视为二项分布。认识到这一事实有助于在肾活检解读中对活检样本大小的影响进行定量评估。如果用活检中肾小球受累的百分比来确定局灶性肾小球病变的严重程度，那么小活检样本量会导致疾病严重程度的大量错误分类。此外，小活检样本量会使局灶性疾病的排除变得困难。
