Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 200072 Shanghai, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, 610065 Chengdu, China.
Mater Sci Eng C Mater Biol Appl. 2021 May;124:112040. doi: 10.1016/j.msec.2021.112040. Epub 2021 Mar 24.
To avoid catastrophic bacterial infection in prosthesis failure, ultrahigh molecular weight polyethylene (UHMWPE), a common bearing material of artificial joints, has been formulated with antibiotics to eliminate bacteria locally at the implant site. However, the pressing issues regarding cytotoxic effects and evolution of drug resistant bacteria necessitates the development of bio-friendly bacteriostat with long bacteriostatic efficacy. Herein, tea polyphenol extracted from nature source was introduced in UHMWPE as a biogenic antimicrobial. Controlled antimicrobial activity was achieved by chemical crosslinking to regulate the release of the tea polyphenol. In addition, the crosslinking efficiency of UHMWPE blends with high loaded tea polyphenol was significantly improved in comparison to radiation crosslinking. The immobilized tea polyphenols also enhanced the oxidation stability of the UHMWPE, which is essential to prolong the service life in vivo and the storage time in vitro. The blends presented good biocompatibility, despite cell repellent on the highly crosslinked surface. Chemically crosslinked tea polyphenol/UHMWPE exhibited feasible properties for total joint implants, which is promising for clinical application.
为了避免假体失效导致的灾难性细菌感染，超高分子量聚乙烯（UHMWPE）作为人工关节的常用轴承材料，已与抗生素联合使用，以在植入部位局部消除细菌。然而，关于细胞毒性作用和耐药菌演变的紧迫问题需要开发具有长效抑菌作用的生物友好型抑菌剂。本文中，从天然来源提取的茶多酚被引入到 UHMWPE 中，作为一种生物抗菌剂。通过化学交联来控制抗菌活性，以调节茶多酚的释放。此外，与辐射交联相比，高负载量茶多酚的 UHMWPE 共混物的交联效率显著提高。固定化的茶多酚还增强了 UHMWPE 的氧化稳定性，这对于延长体内使用寿命和体外储存时间至关重要。尽管高交联表面具有细胞排斥性，但共混物仍表现出良好的生物相容性。化学交联的茶多酚/UHMWPE 表现出了全关节植入物的可行性能，有望应用于临床。
