West China School of Nursing, Sichuan University/West China Hospital, Sichuan University, Chengdu, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China.
J Biomed Mater Res B Appl Biomater. 2023 Jan;111(1):26-37. doi: 10.1002/jbm.b.35129. Epub 2022 Jul 9.
Vitamin E (VE) is currently an approved antioxidant to improve the oxidation stability of highly crosslinked ultrahigh molecular weight polyethylene (UHMWPE) insert used commercially in total joint arthroplasty. However, the decrease in crosslink density caused by VE reduces wear resistance of UHMWPE, showing an uncoordinated challenge. In this work, we hypothesized that D-sorbitol (DS) as a secondary antioxidant can improve the antioxidant efficacy of VE on chemically crosslinked UHMWPE. The combined effect of VE and DS on oxidation stability of UHMWPE was investigated at a set of controlled hybrid antioxidant content. The hybrid antioxidant strategy showed significantly synergistic enhancement on the oxidation stability of chemically crosslinked UHMWPE compared with the single VE strategy. More strikingly, the crosslink density of the blends with hybrid antioxidants stayed at a high level since DS is not sensitive to crosslinking. The relationships between oxidation stability, mechanical properties, crosslink density, and crystallinity were investigated, by which the clinically relevant overall performance of UHMWPE was optimized. This work provides a leading-edge design mean for the development of joint bearings.
维生素 E (VE) 目前被批准为一种抗氧化剂，用于提高商用的全髋关节置换术中使用的高度交联超高相对分子质量聚乙烯 (UHMWPE) 植入物的氧化稳定性。然而，VE 导致的交联密度降低会降低 UHMWPE 的耐磨性，表现出不协调的挑战。在这项工作中，我们假设 D-山梨糖醇 (DS) 作为一种辅助抗氧化剂可以提高 VE 对化学交联 UHMWPE 的抗氧化效果。在一组控制的混合抗氧化剂含量下，研究了 VE 和 DS 对 UHMWPE 氧化稳定性的联合作用。与单一 VE 策略相比，混合抗氧化剂策略对化学交联 UHMWPE 的氧化稳定性表现出显著的协同增强作用。更引人注目的是，由于 DS 对交联不敏感，因此混合抗氧化剂的交联密度保持在较高水平。通过研究氧化稳定性、力学性能、交联密度和结晶度之间的关系，优化了 UHMWPE 的临床相关整体性能。这项工作为关节轴承的开发提供了一个前沿的设计手段。
