Elkin I, Pilkonis P A, Docherty J P, Sotsky S M
NIMH Treatment of Depression Collaborative Research Program, Rockville, MD 20857.
Am J Psychiatry. 1988 Aug;145(8):909-17. doi: 10.1176/ajp.145.8.909.
There has recently been an increased focus on comparing the effectiveness of drugs and psychotherapy in the treatment of mental disorders. The marked differences between these two treatment forms raise many conceptual and methodological problems for the investigator. In a two-part series, the authors discuss a number of these conceptual issues and their implications for research design, implementation, and interpretation of findings. Part I focuses on differences in the active ingredients and hypothesized mechanisms of change of psychotherapy and pharmacotherapy. Issues addressed include the need for standardization of treatments, adequate delivery of treatments, and controlling for factors other than the active ingredients of each treatment.
最近，人们越来越关注比较药物治疗和心理治疗在精神障碍治疗中的有效性。这两种治疗形式之间的显著差异给研究者带来了许多概念和方法上的问题。在一个分为两部分的系列文章中，作者讨论了其中一些概念性问题及其对研究设计、实施和结果解释的影响。第一部分重点关注心理治疗和药物治疗的活性成分差异以及假设的变化机制。涉及的问题包括治疗标准化的必要性、治疗的充分实施以及控制每种治疗活性成分以外的因素。
