Nanjing Institute for Food and Drug Control, Nanjing, P. R. China.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China.
Nat Prod Res. 2022 May;36(10):2526-2533. doi: 10.1080/14786419.2021.1913590. Epub 2021 May 5.
A phytochemical investigation on the fruits of led to the isolation and characterisation of a new prenylated coumarin, artoheteronin (), together with six known analogues (-). The chemical structure of was elucidated using extensive spectral methods and the known compounds (-) were identified by comparing their spectral data with those reported in the literature. All known compounds (-) were isolated from the genus for the first time. The anti-inflammatory and anti-HIV activities of all isolated prenylated coumarins (1-7) were assessed As a result, compounds - displayed notable inhibitory effects against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with the IC values in range of 0.58 ± 0.06 to 6.29 ± 0.12 μM. Meanwhile, compounds - exhibited notable anti-HIV-1 reverse transcriptase (RT) activities possessing EC values in the range of 0.18 to 9.12 µM.
对 led 的果实进行植物化学研究，分离并鉴定了一种新的prenylated coumarin，artoheteronin ()，以及六种已知类似物 (-)。通过广泛的光谱方法阐明了 的化学结构，通过将已知化合物的光谱数据与文献中报道的数据进行比较，鉴定了已知化合物 (-)。所有已知化合物 (-)均首次从 属中分离得到。评估了所有分离出的prenylated coumarins (1-7) 的抗炎和抗 HIV 活性。结果表明，化合物 - 对脂多糖诱导的小鼠巨噬细胞 RAW 264.7 细胞中一氧化氮 (NO) 产生具有显著的抑制作用，IC 值在 0.58±0.06 至 6.29±0.12 μM 范围内。同时，化合物 - 表现出显著的抗 HIV-1 逆转录酶 (RT) 活性，EC 值在 0.18 至 9.12 μM 范围内。
