Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia.
Leibniz Institute of Polymer Research Dresden, 01005 Dresden, Germany.
Int J Mol Sci. 2023 Feb 2;24(3):2839. doi: 10.3390/ijms24032839.
This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins.
本综述总结和系统化了植物香豆素的抗 HIV 活性的文献，重点介绍了它们的分离和抗病毒作用机制。本综述总结了简单香豆素以及芳基呋喃并和吡喃香豆素的抗 HIV 特性的信息，表明植物来源的香豆素可以通过几种机制发挥作用：抑制 HIV 逆转录酶和整合酶，抑制调节 HIV-1 复制的细胞因子，以及将病毒颗粒从感染的巨噬细胞传递到健康细胞。值得注意的是，一些吡喃香豆素能够通过几种机制发挥作用或与多个位点结合，从而确保这些化合物对 HIV 突变具有抗性。在这里，我们回顾了过去二十年关于天然香豆素的抗 HIV 活性的研究。
