Lv Jian-Hua, Yao Lan, Duan Chao, Li Zhuang, Zhang Jun, Li Chang-Tian, Li Yu
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, PR China.
College of Life Science, Hebei University, Baoding, PR China.
Nat Prod Res. 2022 Jun;36(11):2707-2712. doi: 10.1080/14786419.2021.1920020. Epub 2021 May 5.
Chemical investigation of (Batsch) Fr. led to the isolation of a pair of new enantiomers ()-5-(4-methoxy-2-oxo-2H-pyran-6-yl)pent-4-en-1-yl 2-hydroxypropanoate (/) along with 14 known compounds (-) for the first time from this mushroom. The structures of new compounds were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by comparison of the experimental and calculated ECD data. Compounds and exhibited radical scavenging activities with IC values ranging from 10.39 ± 2.26 to 20.43 ± 3.74 μg/mL. Compounds and also showed moderate anti-tyrosinase activity with IC value of 25.66 ± 2.84 and 26.82 ± 3.19 μg/mL.
对（巴氏）弗氏菌的化学研究首次从这种蘑菇中分离出一对新的对映体（±）-5-（4-甲氧基-2-氧代-2H-吡喃-6-基）戊-4-烯-1-基 2-羟基丙酸酯（/）以及14种已知化合物（-）。基于质谱、一维和二维核磁共振的广泛光谱数据分析阐明了新化合物的结构，并通过比较实验和计算的电子圆二色光谱数据确定了它们的绝对构型。化合物和表现出自由基清除活性，IC值范围为10.39±2.26至20.43±3.74μg/mL。化合物和还表现出中等的抗酪氨酸酶活性，IC值分别为25.66±2.84和26.82±3.19μg/mL。
