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肠道微生物组和抗药性组在 COVID-19 大流行第一波期间的变化与大流行前与旅行相关的变化相比。

Gut microbiome and resistome changes during the first wave of the COVID-19 pandemic in comparison with pre-pandemic travel-related changes.

机构信息

HKU-Pasteur Research Pole, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR.

School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR.

出版信息

J Travel Med. 2021 Oct 11;28(7). doi: 10.1093/jtm/taab067.

DOI:10.1093/jtm/taab067
PMID:33949663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8135950/
Abstract

COVID-19-associated measures had a greater impact on gut microbiota, ARGs, and BRGs than did pre-pandemic international travel. During the COVID-19 pandemic, Actinobacteria richness decreased while genes conferring resistance to beta-lactam, polystyrene and phthalate increased. Such alterations may affect both colonisation resistance and acquisition and spread of antimicrobial resistance in future travels.

摘要

新冠疫情相关措施对肠道微生物群、抗生素耐药基因和细菌耐药基因的影响大于大流行前的国际旅行。在新冠疫情期间，放线菌丰富度下降，而对β-内酰胺、聚苯乙烯和邻苯二甲酸酯具有抗性的基因增加。这些变化可能会影响未来旅行中定植抵抗力以及抗生素耐药性的获得和传播。

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