Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Italy.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Curr Med Chem. 2021;28(37):7595-7613. doi: 10.2174/0929867328666210504113445.
The Mediterranean diet is worldwide recognized as a good prototype of nutrition due to the conspicuous intake of olive oil, nuts, red wine, legumes, fruit, and vegetables, all fundamental elements rich in antioxidant substances and polyphenols. Polyphenols are a wide range of phytochemicals and/or synthetic chemical compounds with proven beneficial properties for human health. In the present review, we critically summarize the wellcharacterized antioxidant and anti-inflammatory properties of polyphenols contained in the olives and extra virgin olive oil and of resveratrol, a non-flavonoid phenolic compound. We discuss the potential use of these polyphenols as pharmaceutical formulations for the treatment of human diseases. We also show the emerging importance of their consumption in the prevention and management of crucial neurodegenerative conditions (alcohol-related brain disorders and aging) and in neuromuscular disorders (Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy), where oxidative stress plays a predominant role.
地中海饮食因大量摄入橄榄油、坚果、红酒、豆类、水果和蔬菜而被公认为良好的营养模式，这些都是富含抗氧化物质和多酚的基本元素。多酚是一大类植物化学物质和/或合成化合物，具有已被证实对人类健康有益的特性。在本综述中，我们批判性地总结了橄榄和特级初榨橄榄油中多酚以及白藜芦醇（一种非类黄酮酚类化合物）的抗氧化和抗炎特性。我们讨论了将这些多酚用作治疗人类疾病的药物制剂的潜在用途。我们还展示了它们在预防和管理关键神经退行性疾病（与酒精相关的脑疾病和衰老）以及神经肌肉疾病（脊髓性肌萎缩症、肌萎缩侧索硬化症和杜氏肌营养不良症）中的新兴重要性，在这些疾病中，氧化应激起着主要作用。
