IEEE Trans Neural Syst Rehabil Eng. 2021;29:872-883. doi: 10.1109/TNSRE.2021.3076983. Epub 2021 May 13.
Insomnia affects millions of people worldwide, and non-pharmacological treatment options are limited. A bed excited with multiple vibration sources was used to explore beat frequency vibration (BFV) as a non-pharmacological treatment for insomnia. A repeated measures design pilot study of 14 participants with mild-moderate insomnia symptom severity (self-reported on the Insomnia Severity Index) was conducted to determine the effects of BFV, and traditional standing wave vibration (SWV) on sleep latency and sleep electrocortical activity. Participants were monitored using high-density electroencephalography (HD-EEG). Sleep latency was compared between treatment conditions. A trend of decreasing sleep latency due to BFV was found for unequivocal sleep latency (p ≤ 0.068). Neural complexity during wake, N1, and N2 stages were compared using Multi-Scale Sample Entropy (MSE), which demonstrated significantly lower MSE between wake and N2 stages (p ≤ 0.002). During N2 sleep, BFV showed lower MSE than the control session in the left frontoparietal region. As a measure of information integration, reduced entropy may indicate that BFV decreases conscious awareness during deeper stages of sleep. SWV caused reduced alpha activity and increased delta activity during wake. BFV caused increased delta activity during N2 sleep. These preliminary results suggest that BFV may help decrease sleep latency, reduce conscious awareness, and increase sleep drive expression during deeper stages of sleep. SWV may be beneficial for decreasing expression of arousal and increasing expression of sleep drive during wake, implying that beat frequency vibration may be beneficial to sleep.
失眠影响着全球数以百万计的人，而非药物治疗选择有限。本研究使用具有多个振动源的床来探索拍频振动（BFV）作为失眠的非药物治疗方法。对 14 名轻度至中度失眠症状严重程度的参与者（根据失眠严重程度指数自我报告）进行了重复测量设计的初步研究，以确定 BFV 和传统驻波振动（SWV）对睡眠潜伏期和睡眠脑电活动的影响。参与者使用高密度脑电图（HD-EEG）进行监测。比较了治疗条件下的睡眠潜伏期。由于 BFV 导致明确的睡眠潜伏期呈降低趋势（p≤0.068）。使用多尺度样本熵（MSE）比较清醒、N1 和 N2 阶段的神经复杂性，结果表明清醒和 N2 阶段之间的 MSE 显著降低（p≤0.002）。在 N2 睡眠期间，BFV 在左额顶区域的 MSE 低于对照期。作为信息整合的度量，熵的降低可能表明 BFV 降低了较深睡眠阶段的意识。SWV 在清醒时引起阿尔法活动减少和德尔塔活动增加。BFV 在 N2 睡眠时引起德尔塔活动增加。这些初步结果表明，BFV 可能有助于缩短睡眠潜伏期、降低意识，并增加较深睡眠阶段的睡眠驱动力表达。SWV 可能有益于减少觉醒表达和增加清醒时的睡眠驱动力表达，这意味着拍频振动可能有益于睡眠。
