Janicke D M, Parker S W, Cafarell R F, Apicella M A, Jusko W J
Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14260.
Antimicrob Agents Chemother. 1988 May;32(5):777-9. doi: 10.1128/AAC.32.5.777.
The pharmacokinetics of mezlocillin at two dosages were studied over the course of therapy in 12 patients receiving the drug for the treatment of infections. Patients received an initial dosing regimen of 4 g every 6 h or 5 g every 8 h, which was switched to the alternative regimen after 5 days of treatment. Both drug regimens demonstrated similar pharmacokinetic characteristics, which suggests that the reported dose-dependent elimination of mezlocillin is not an important factor in the clinical use of mezlocillin at the dosages currently used.
在12名接受美洛西林治疗感染的患者的治疗过程中，研究了两种剂量美洛西林的药代动力学。患者接受的初始给药方案为每6小时4克或每8小时5克，治疗5天后改为另一种方案。两种给药方案均显示出相似的药代动力学特征，这表明所报道的美洛西林剂量依赖性消除在目前所用剂量的美洛西林临床应用中并非重要因素。
