Clough J V, Farrell I D, Wood M J, Leyland M J
J Antimicrob Chemother. 1985 Mar;15(3):353-63. doi: 10.1093/jac/15.3.353.
Sixty episodes of fever in neutropenic patients with haematological malignancy were treated with ceftazidime and mezlocillin. Improvement or temporary improvement was seen in 76% of patients with microbiologically or clinically documented infection. Fifty-seven per cent of episodes due to bacteraemia improved with the antibiotics. Escherichia coli and Staphylococcus aureus were the commonest pathogens isolated; bacteraemia due to Staph. epidermis was not encountered. The toxicity of ceftazidime plus mezlocillin was acceptable. Diarrhoea developed in 12% and a skin rash in 10%.
用头孢他啶和美洛西林治疗60例血液系统恶性肿瘤中性粒细胞减少患者的发热。在微生物学或临床确诊感染的患者中，76%有改善或暂时改善。由菌血症引起的发热发作，57%使用抗生素后得到改善。分离出的最常见病原体为大肠杆菌和金黄色葡萄球菌；未发现表皮葡萄球菌引起的菌血症。头孢他啶加美洛西林的毒性可以接受。12%的患者出现腹泻，10%出现皮疹。
