From the Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China (Z.P., C.C.W., X.P., L.X., H.Y., Y.X.W., J.B.J.); Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Z.P.).
From the Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China (Z.P., C.C.W., X.P., L.X., H.Y., Y.X.W., J.B.J.); Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China (C.C.W., W.B.W.).
Am J Ophthalmol. 2021 Oct;230:68-74. doi: 10.1016/j.ajo.2021.04.018. Epub 2021 May 2.
To assess the prevalence of myelinated retinal nerve fibers (MRNFs), the rate of their change in a 10-year follow-up, and associations with ocular and systematic parameters in a population-based cohort.
Longitudinal population-based cohort study.
The Beijing Eye study including 4,439 participants aged 40+ years in 2001 and was repeated in 2011, with 2,695 individuals (66.4% of the surviving) being re-examined in 2011. All participants underwent detailed physical and ocular examinations. MRNFs were diagnosed on fundus photographs and their change was assessed using a flicker method of fundus photographs.
Out of 35 eyes (29 participants) with detected MRNFs at baseline (mean prevalence: 0.4% ± 0.26% per eye or 0.7% ± 0.41% per individual), 23 eyes from 20 individuals (17 [85%] participants with unilateral MRNFs) were re-examined in 2011. MRNF enlargement was detected in all 19 eyes (100%) with clear fundus photographs. The mean MRNF area increased from 4,233 ± 3,670 µm (range: 178-11,643 µm) at baseline to 5,243 ± 4,092 µm (range: 196-13,297 µm) at follow-up (P < .001), by 1,010 ± 1,026 µm (18-3,967 µm) or by 47% ± 74% (9%-315%). A larger MRNF increase was associated with an MRNF location distant from the optic disc as compared to a juxtapapillary location (P = .001, standardized regression coefficient beta: -0.53), smaller MRNF area at baseline (P = .006, beta: -0.34), and higher serum concentration of low-density lipoproteins (LDL) (P < .001, beta: 0.57).
MRNFs (mean prevalence per eye: 0.4%) showed, in association with higher LDL serum concentration and peripheral located MRNF, an enlargement during a 10-year follow-up, while in the same period no new MRNFs were detected in the total study cohort.
评估有髓神经纤维（MRNFs）的患病率，在 10 年随访期间的变化率，以及与人群中眼部和系统参数的相关性。
基于人群的纵向队列研究。
北京眼研究包括 2001 年的 4439 名 40 岁以上参与者，2011 年重复进行，其中 2695 名（幸存人数的 66.4%）在 2011 年再次接受检查。所有参与者均接受了详细的身体和眼部检查。在眼底照片上诊断出 MRNFs，并使用眼底照片闪烁法评估其变化。
在基线时（每只眼的平均患病率：0.4%±0.26%，或每个人的 0.7%±0.41%）检测到 35 只眼睛（29 名参与者）有 MRNFs，其中 20 名参与者中有 23 只眼睛（17 名单侧 MRNFs 参与者）在 2011 年再次接受检查。所有 19 只眼睛（100%）的眼底照片清晰可见，MRNF 增大。MRNF 面积从基线时的 4233±3670 µm（范围：178-11643 µm）增加到随访时的 5243±4092 µm（范围：196-13297 µm）（P<.001），增加了 1010±1026 µm（18-3967 µm）或增加了 47%±74%（9%-315%）。与视盘旁位置相比，MRNF 位置远离视盘与更大的 MRNF 增加相关（P=.001，标准化回归系数β：-0.53），基线时的 MRNF 面积较小（P=.006，β：-0.34），以及较低密度脂蛋白（LDL）血清浓度较高（P<.001，β：0.57）。
MRNFs（每只眼的平均患病率：0.4%）在 10 年随访期间与较高的 LDL 血清浓度和外周位置的 MRNF 相关，出现增大，而在同期的总研究队列中没有发现新的 MRNFs。
