Department of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Department of Ophthalmology, EYE & ENT Hospital of Fudan University, 19 Baoqing Road, Shanghai, 200031, China.
BMC Ophthalmol. 2024 Oct 24;24(1):467. doi: 10.1186/s12886-024-03733-x.
To investigate the fundus characteristics and macular optical coherence tomography angiography (OCTA) metrics in patients with myelinated retinal nerve fibers (MRNF) and to identify the associations among myopic parameters, fundus metrics, and OCTA metrics.
The single-center case-control study included 15 patients with monocular MRNF and 15 patients without MRNF, matched for age, affected eyes' spherical equivalent error (SER), and axial length (AL) between May 2021 and December 2021. Fundus features, including the entire MRNF area (Area1), the denser MRNF area (Area2), and the shortest distance from the fovea to the MRNF border (D), along with ocular parameters, including SER, AL, best corrected visual acuity (BCVA), and OCTA metrics at the fovea, including choroidal (ChT) and retinal (ReT) thicknesses at the fovea, the foveal avascular zone area (FAZ), foveal avascular zone perimeter (FAZP), FAZ-circularity index (FAZ-CI), and foveal vessel density in a 300-µm wide region (FD-300), were assessed.
The SER, AL, and BCVA were significantly different, and the ChT was thinner in the affected eyes than in the contralateral eyes. Compared with matched eyes, affected eyes had reduced BCVA and thinner ReT. In the affected eyes, both Area1 and Area2 were negatively correlated with SER (r = -0.84, r = -0.65), △SER (r = -0.86, r = -0.61), ReT at the vertical superior 3 mm (VS) (r = -0.78, r = -0.67), and ChT_VS (r = -0.64, r = -0.62), and positively correlated with AL (r = 0.82, r = 0.52) and BCVA (r = 0.54, r = 0.59). D was negatively correlated with BCVA (r = -0.57).
The presence of MRNF affects BCVA and ReT at the fovea. The area of the MRNF, as well as the distance from the MRNF to the fovea, are closely associated with the affected eyes' BCVA, SER, AL, and the degree of anisometropia.
研究有髓神经纤维（MRNF）患者的眼底特征和黄斑光学相干断层扫描血管造影（OCTA）指标，并探讨近视参数、眼底指标和 OCTA 指标之间的相关性。
本单中心病例对照研究纳入了 2021 年 5 月至 12 月期间的 15 名单侧 MRNF 患者和 15 名无 MRNF 患者，这些患者在年龄、受影响眼的等效球镜误差（SER）和眼轴长度（AL）方面相匹配。记录患者的眼底特征，包括整个 MRNF 区域（Area1）、密度较大的 MRNF 区域（Area2）和从黄斑到 MRNF 边界的最短距离（D），以及眼参数，包括 SER、AL、最佳矫正视力（BCVA）和黄斑区 OCTA 指标，包括黄斑区脉络膜（ChT）和视网膜（ReT）厚度、中心凹无血管区面积（FAZ）、中心凹无血管区周长（FAZP）、FAZ 圆度指数（FAZ-CI）和 300µm 宽区域的血管密度（FD-300）。
受影响眼的 SER、AL 和 BCVA 存在显著差异，且 ChT 较对侧眼薄。与匹配眼相比，受影响眼的 BCVA 降低，ReT 变薄。在受影响眼中，Area1 和 Area2 与 SER（r=-0.84，r=-0.65）、△SER（r=-0.86，r=-0.61）、垂直上方 3mm 处的 ReT（r=-0.78，r=-0.67）和 ChT_VS（r=-0.64，r=-0.62）呈负相关，与 AL（r=0.82，r=0.52）和 BCVA（r=0.54，r=0.59）呈正相关。D 与 BCVA 呈负相关（r=-0.57）。
MRNF 的存在会影响黄斑区的 BCVA 和 ReT。MRNF 的面积以及其与黄斑的距离与受影响眼的 BCVA、SER、AL 和屈光参差程度密切相关。
