Emudianughe T S
Department of Clinical Pharmacology, Faculty of Health Sciences, University of Ilorin, Nigeria.
Arch Int Pharmacodyn Ther. 1988 Mar-Apr;292:7-12.
Subjects (7 males and 7 females) were dosed with salicylic acid (1 g) and hourly urinary samples were analyzed for its metabolites. The results obtained showed that the female subjects had higher capacity for salicylurate formation than the male (P less than or equal to 0.025). The urinary hourly excretion ratio of salicylurate and salicylglucuronic acid was about or greater than 1 while in the male this ratio is less than 0.50. A comparison of this ratio between female and male showed a highly significant difference (P less than or equal to 0.001). The high capacity of glucuronic acid pathway in male and the alternate pathway in female suggest a possible genetic influence in salicylic acid metabolism.
研究对象（7名男性和7名女性）服用水杨酸（1克），并每小时对尿液样本进行代谢物分析。所得结果表明，女性受试者形成水杨尿酸的能力高于男性（P≤0.025）。水杨尿酸与水杨酸葡萄糖醛酸的每小时尿排泄率约为1或大于1，而男性的这一比率小于0.50。男性和女性之间这一比率的比较显示出高度显著差异（P≤0.001）。男性葡萄糖醛酸途径的高能力和女性的替代途径表明水杨酸代谢可能受遗传影响。
