Emudianughe T S
Department of Isotope Research, Weizmann Institute of Science, Rehovot, Israel.
Fundam Clin Pharmacol. 1990;4(5):483-9. doi: 10.1111/j.1472-8206.1990.tb00033.x.
The metabolism of salicylic acid was studied in male and female streptozotocin-induced diabetic Wistar rats. Results obtained showed that in both sexes there was a significant increase in urinary excretion of salicyluric acid in diabetic rats when compared to controls (P less than or equal to 0.001). Within the diabetic groups, there was a significant increase in the urinary excretion of salicyluric acid in the female in comparison to the male rats (P less than or equal to 0.01). A statistically significant increase was observed in urinary excretion of salicyl-glucuronic acid in diabetic female compared to control female rats (P less than or equal to 0.01) while comparison of diabetic male to control male showed a significant decrease in urinary excretion of salicyl-glucuronic acid (P less than or equal to 0.01). Comparison of the diabetic female and male groups showed a high statistically significant difference in urinary excretion of salicyl-glucuronic acid. The diabetic ration, ie diabetic/control was significantly higher in female than in male rats with respect to salicyl-glucuronic acid (P less than or equal to 0.001) and total urinary excretion (P less than or equal to 0.01). The diabetic ratio may likely reflect the true significance of the roles played by the two metabolic pathways. The results suggest sex differences in the metabolism of salicylic acid; this may also be the case in other disease states.
在雄性和雌性链脲佐菌素诱导的糖尿病Wistar大鼠中研究了水杨酸的代谢。所得结果表明，与对照组相比，糖尿病大鼠中尿水杨酸的排泄量在两性中均显著增加（P≤0.001）。在糖尿病组中，雌性大鼠尿水杨酸的排泄量比雄性大鼠显著增加（P≤0.01）。与对照雌性大鼠相比，糖尿病雌性大鼠尿水杨酰葡萄糖醛酸的排泄量有统计学意义的显著增加（P≤0.01），而糖尿病雄性大鼠与对照雄性大鼠相比，尿水杨酰葡萄糖醛酸的排泄量显著减少（P≤0.01）。糖尿病雌性和雄性组之间在尿水杨酰葡萄糖醛酸的排泄量上显示出高度统计学显著差异。就水杨酰葡萄糖醛酸（P≤0.001）和总尿排泄量（P≤0.01）而言，糖尿病比率（即糖尿病组/对照组）在雌性大鼠中显著高于雄性大鼠。糖尿病比率可能反映了两种代谢途径所起作用的真正意义。结果表明水杨酸代谢存在性别差异；在其他疾病状态下可能也是如此。
