Centre for Water Research, Department of Civil and Environmental Engineering, Faculty of Engineering, National University of Singapore, Singapore.
School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266033, PR China.
J Hazard Mater. 2021 Jun 15;412:125229. doi: 10.1016/j.jhazmat.2021.125229. Epub 2021 Jan 27.
The complex organics, residue pharmaceuticals and high salinity in pharmaceutical wastewater pose great challenges to biological wastewater treatment. In this study, granular sludge process was used for treating pharmaceutical wastewater because of its high pollutant removal efficiency. The results suggested that granules could not form within 90-d cultivation when directly fed with target hypersaline pharmaceutical wastewater (R) due to suppression of EPS secretion by high concentration of inhibitory organics, while granules were successfully developed with hypersaline synthetic wastewater (R) and diluted pharmaceutical wastewater (R), respectively. Further comparison of pollutant removal performance from target pharmaceutical wastewater showed that simultaneous removal of organics (effluent bCOD<1 mg L) and nitrogen (average TN removal efficiency of 70.3%) could be achieved in R. Nevertheless, long acclimation period (i.e., 20 d) was needed for granules when carbon source was shifted from simple sodium acetate to complex organic pollutants in pharmaceutical wastewater, with nitrite significantly accumulated in R. Analysis of microbial community and nitrogen metabolism pathway indicated the higher abundance of nitrite oxidoreductase than that in the R to alleviate nitrite accumulation in the R, and functional strains such as Paracoccus and Mycobacterium played critical roles for high efficiency of organic degradation, nitrification and denitrification.
制药废水中复杂的有机物、残留药物和高盐度对生物废水处理构成了巨大挑战。在这项研究中，由于其具有较高的污染物去除效率，采用颗粒污泥工艺处理制药废水。结果表明，由于高浓度抑制性有机物抑制 EPS 分泌，直接用目标高盐制药废水（R）进料时，90 天内无法形成颗粒，但分别用高盐合成废水（R）和稀释制药废水（R）成功开发了颗粒。进一步比较从目标制药废水中去除污染物的性能表明，在 R 中可以同时去除有机物（出水 bCOD<1mg/L）和氮（平均 TN 去除效率为 70.3%）。然而，当碳源从简单的乙酸钠转变为制药废水中的复杂有机污染物时，颗粒需要较长的驯化期（即 20 天），并且在 R 中会显著积累亚硝酸盐。微生物群落和氮代谢途径的分析表明，R 中亚硝酸氧化还原酶的丰度高于 R，以缓解 R 中亚硝酸盐的积累，而 Paracoccus 和 Mycobacterium 等功能菌株对高效降解有机物、硝化和反硝化起着关键作用。
