Yen Y, Schmiemann C, Damjanov I
Department of Pathology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Arch Pathol Lab Med. 1988 Aug;112(8):791-3.
Lectin histochemistry was used to compare normal endometrial and endocervical epithelium with adenocarcinomas arising in these locations. Endometrial carcinomas were characterized by much more variable lectin binding than normal endometrial cells. Endocervical carcinomas essentially retained the phenotype of parental epithelium. Type I lectin from Griffonia simplicifolia was the only lectin consistently nonreactive with normal endocervix that reacted with all endocervical carcinomas. In both anatomic sites, malignant transformation was associated with a loss of binding sites for some lectins and an acquisition of binding sites for others.
采用凝集素组织化学方法，对正常子宫内膜和宫颈上皮及其发生的腺癌进行比较。与正常子宫内膜细胞相比，子宫内膜癌的凝集素结合变化更大。宫颈腺癌基本保留了亲代上皮的表型。来自西非单叶豆的I型凝集素是唯一一种与正常宫颈始终无反应，但与所有宫颈腺癌均有反应的凝集素。在这两个解剖部位，恶性转化均与某些凝集素结合位点的丧失及其他凝集素结合位点的获得有关。
