Czernobilsky B, Katz Z, Lancet M, Gaton E
Am J Surg Pathol. 1980 Oct;4(5):481-9.
A review of the histologic material from 100 patients with endometrial carcinoma revealed 10 cases in which endocervical-type epithelium constituted an integral component of endometrial adenocarcinoma. In nine of these, the endocervical epithelium was focal while in one patient, reported in detail, the curetted endometrial carcinoma presented as an almost pure endocervical-type lesion. In most instances, the endocervical epithelium was papillary and mature, but areas of tufting, pseudostratification and atypism were also evident. Endocervical-type epithelium in endometrial cancers was more common in curettings than in hysterectomy specimens probably because of its superficial location within the tumor. The endocervical nature of these components, which are most likely of metaplastic origin, was evident on light and electron microscopy. Histochemical stains established the similarities of the cytoplasmic mucins of these cells to that of normal endocervix and well-differentiated endocervical adenocarcinoma and emphasized the dissimilarities to the mucin content of papillary, secretory and clear-cell endometrial carcinoma. Thus, awareness of this type of lesion, application of strict histologic criteria and use of histochemical stains make it possible to reach the correct diagnosis in most cases, even in those in which the endocervical-type epithelium composes the major portion of curettings from an endometrial adenocarcinoma.
对100例子宫内膜癌患者的组织学材料进行回顾性研究发现，其中10例患者的子宫内膜腺癌中宫颈内膜型上皮是其重要组成部分。其中9例患者的宫颈内膜上皮为局灶性，而在1例详细报道的患者中，刮出的子宫内膜癌几乎呈现为纯粹的宫颈内膜型病变。在大多数情况下，宫颈内膜上皮呈乳头状且成熟，但也可见簇状、假复层和异型性区域。子宫内膜癌中的宫颈内膜型上皮在刮宫标本中比在子宫切除标本中更常见，这可能是因为其在肿瘤中的位置较浅。这些成分很可能起源于化生，其宫颈内膜的性质在光学显微镜和电子显微镜下均很明显。组织化学染色显示这些细胞的细胞质粘蛋白与正常宫颈内膜及高分化宫颈内膜腺癌的相似，同时也强调了与乳头状、分泌性和透明细胞型子宫内膜癌粘蛋白含量的差异。因此，认识到这类病变，应用严格的组织学标准并使用组织化学染色，即使在宫颈内膜型上皮构成子宫内膜腺癌刮宫标本主要部分的病例中，大多数情况下也能做出正确诊断。
