The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan;
Department of Internal Medicine, Division of gastroenterology and hepatology, Hyogo College of Medicine, Nishinomiya, Japan.
Anticancer Res. 2021 May;41(5):2227-2237. doi: 10.21873/anticanres.14999.
Lifestyle-related factors play a major role in the development of cancer. In recent years, obesity has become widespread in the world and has attracted attention not only as a cause of diabetes mellitus and atherosclerotic diseases but also as a factor in carcinogenesis. In Japan, the number of obesity-related malignancies has been increasing with the westernization of lifestyle. On the other hand, it is estimated that there are more than 10 million nonalcoholic fatty liver disease (NAFLD) patients in Japan. NAFLD is classified into simple fatty liver and nonalcoholic steatohepatitis (NASH), and 10-20% of NASH patients will progress to liver cirrhosis and 2-3% of them will develop hepatocellular carcinoma (HCC) per year. Research interest in metabolism-associated liver cancer has been increasing in recent years. Here in this review, we will comprehensively summarize the current knowledge with regard to the relationship between obesity and HCC in Japan.
生活方式相关因素在癌症的发展中起着重要作用。近年来，肥胖在世界范围内广泛存在，不仅作为糖尿病和动脉粥样硬化性疾病的病因引起关注，而且作为致癌因素引起关注。在日本，与肥胖相关的恶性肿瘤的数量随着生活方式的西化而增加。另一方面，据估计，日本有超过 1000 万名非酒精性脂肪性肝病 (NAFLD) 患者。NAFLD 分为单纯性脂肪肝和非酒精性脂肪性肝炎 (NASH)，10-20%的 NASH 患者将进展为肝硬化，每年有 2-3%的患者将发展为肝细胞癌 (HCC)。近年来，人们对代谢相关肝癌的研究兴趣日益增加。在这篇综述中，我们将全面总结日本肥胖与 HCC 之间关系的现有知识。
