日本溃疡性结肠炎相关性结直肠癌的术后生存情况：一项多中心分析。

Postoperative Survival in Colitis-associated Colorectal Cancer With Ulcerative Colitis in Japan: A Multicenter Analysis.

机构信息

Department of Inflammatory Bowel Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Japan;

Surgical Department of Inflammatory Bowel Disease, Hyogo Medical University, Nishinomiya, Japan.

出版信息

Anticancer Res. 2021 May;41(5):2681-2688. doi: 10.21873/anticanres.15049.

DOI:10.21873/anticanres.15049

PMID:33952499

Abstract

BACKGROUND/AIM: The aim of the study was to analyze the postoperative survival of colitis-associated colorectal cancer (CAC) with ulcerative colitis (UC), and the risk factors affecting it.

PATIENTS AND METHODS

A questionnaire including postoperative survival was sent to 88 hospitals that reported CAC patients in the literature up until January, 2006 and to members of the Research Group of Intractable Inflammatory Bowel Disease.

RESULTS

The 5-year postoperative overall survival (OS) of 170 CAC patients was 74.2% which was similar to sporadic colorectal cancer in Japan (72.1%). Pathologic TNM stage, histological type, type of surgical procedure (proctocolectomy, segmental resection), and preoperative cancer surveillance were statistically significant factors for OS. By Cox regression analysis, pathologic TNM stage and proctocolectomy were statistically significant prognostic factors for OS.

CONCLUSION

In CAC with UC, the postoperative OS was similar to sporadic colorectal cancer. Pathologic TNM stage and proctocolectomy were confirmed as important prognostic factors.

摘要

背景/目的：本研究旨在分析伴有溃疡性结肠炎（UC）的结肠炎相关性结直肠癌（CAC）的术后生存情况及其影响因素。

方法

本研究向截至 2006 年 1 月在文献中报告 CAC 患者的 88 家医院和难治性炎症性肠病研究组的成员发送了一份包含术后生存情况的问卷。

结果

170 例 CAC 患者的 5 年总生存率（OS）为 74.2%，与日本散发性结直肠癌（72.1%）相似。病理 TNM 分期、组织学类型、手术类型（直肠结肠切除术、节段切除术）和术前癌症监测是 OS 的统计学显著因素。通过 Cox 回归分析，病理 TNM 分期和直肠结肠切除术是 OS 的统计学显著预后因素。