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新冠疫情封锁期间中重度哮喘队列中哮喘恶化的流行情况。

Asthma exacerbation prevalence during the COVID-19 lockdown in a moderate-severe asthma cohort.

机构信息

Pulmonary Medicine, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands

Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.

出版信息

BMJ Open Respir Res. 2021 May;8(1). doi: 10.1136/bmjresp-2020-000758.

DOI:10.1136/bmjresp-2020-000758
PMID:33952584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8102860/
Abstract

INTRODUCTION

Following the recent COVID-19 lockdown, a reduction in emergency healthcare visits was reported. Infectious diseases were less often diagnosed, while it was not clear if this was due to a decrease in prevalence or a decrease in emergency healthcare visits due to fear of COVID-19.

METHODS

This study comprises a follow-up from a recently finished randomised controlled trial, to gain insight into the prevalence of asthma exacerbation and fear of COVID-19 in patients with moderate-severe asthma and controls in the Netherlands. Participants, patients with asthma and controls, were invited to fill out a short survey by email or post. Exacerbation frequencies until 1 July 2020 were verified with the hospitals' and general practitioners' medical records, pharmacies and patient interviews.

RESULTS

In quarter 2 of 2020, mean exacerbation frequency per patient was significantly lower (χ(3)=9.91, p=0.019) compared with quarter 2 in previous years. Patients with asthma were more likely to avoid (38.8%; controls, 0.0%, p<0.01) or delay (24.5%; controls, 0.0%, p=0.02) essential medical visits due to fear of SARS-CoV-2 infection at medical facilities.

CONCLUSION

In conclusion, we found a significantly reduced asthma exacerbation frequency during COVID-19 social distancing measures compared with previous years. Patients with asthma also showed more anxiety towards (acquiring) COVID-19 infection.

TRIAL REGISTRATION NUMBER

NL8576.

摘要

简介

最近的 COVID-19 封锁后,报道称急诊医疗就诊量有所减少。传染病的诊断也减少了,但尚不清楚这是由于患病率下降还是由于对 COVID-19 的恐惧而减少了急诊医疗就诊量。

方法

本研究是对最近完成的一项随机对照试验的随访,旨在深入了解荷兰中度至重度哮喘患者和对照者中哮喘恶化和对 COVID-19 的恐惧的患病率。通过电子邮件或邮寄邀请参与者(哮喘患者和对照者)填写简短的调查问卷。直到 2020 年 7 月 1 日,通过医院和全科医生的病历、药房和患者访谈来验证加重频率。

结果

在 2020 年第 2 季度,每位患者的平均加重频率明显较低(χ(3)=9.91,p=0.019),与前几年的第 2 季度相比。由于害怕在医疗机构感染 SARS-CoV-2,哮喘患者更有可能避免(38.8%;对照组,0.0%,p<0.01)或延迟(24.5%;对照组,0.0%,p=0.02)基本医疗就诊。

结论

总之,我们发现与前几年相比,在 COVID-19 社交距离措施期间,哮喘加重的频率明显降低。哮喘患者对(获得)COVID-19 感染也表现出更多的焦虑。

临床试验注册号

NL8576。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35a/8102860/7881152e7ffb/bmjresp-2020-000758f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35a/8102860/7881152e7ffb/bmjresp-2020-000758f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35a/8102860/7881152e7ffb/bmjresp-2020-000758f01.jpg

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