Pharmacology of Neuroplasticity Laboratory, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil, 14049-900,
Pharmacology of Neuroplasticity Laboratory, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil, 14049-900.
eNeuro. 2021 Jun 2;8(3). doi: 10.1523/ENEURO.0027-21.2021. Print 2021 May-Jun.
The Coronavirus disease-2019 (COVID-19) presents a variability of clinical symptoms, ranging from asymptomatic to severe respiratory and systemic conditions. In a cohort of patients, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), beyond the classical respiratory manifestations, induces anosmia. Evidence has suggested SARS-CoV-2-induced anosmia can be the result of neurodegeneration of the olfactory pathway. Neurologic symptoms associated with COVID-19 have been reported; however, the precise mechanism and possible long-lasting effects remain poorly investigated. Preclinical models are valuable tools for describing and testing new possible treatments for neurologic disorders. In this way, the zebrafish () organism model represents an attractive tool in the field of neuroscience, showing economic and logistic advantages besides genetic and physiologic similarities with mammalian, including the brain structure and functions. Besides, its external embryonic development, high availability of eggs, and fast development allows easy genetic manipulation and fast replications. In the present review, we suggest that the zebrafish model can be advantageous to investigate the neurologic features of COVID-19.
新型冠状病毒病-2019（COVID-19）表现出多种临床症状，从无症状到严重的呼吸道和全身疾病。在一组患者中，严重急性呼吸综合征冠状病毒（SARS-CoV-2）除了经典的呼吸道表现外，还会引起嗅觉丧失。有证据表明，SARS-CoV-2 引起的嗅觉丧失可能是嗅觉通路神经退行性变的结果。与 COVID-19 相关的神经系统症状已被报道；然而，确切的机制和可能的长期影响仍未得到充分研究。临床前模型是描述和测试神经紊乱新的可能治疗方法的有价值的工具。在这方面，斑马鱼（）生物体模型在神经科学领域是一种有吸引力的工具，除了与哺乳动物（包括大脑结构和功能）的遗传和生理相似性外，还具有经济和后勤优势。此外，其外部胚胎发育、大量卵子的供应以及快速的发育允许进行简单的基因操作和快速复制。在本综述中，我们提出斑马鱼模型可以有利于研究 COVID-19 的神经特征。
