Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran.
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Tadulako.
Chem Pharm Bull (Tokyo). 2021;69(5):432-443. doi: 10.1248/cpb.c20-00763.
Ulvan is a natural sulfated polysaccharide obtained from marine green algae composed of 3-sulfated rhamnoglucuronan as the main component. It has a unique chemical structure that rich of L-rhamnosa, D-glucuronic acid, and L-iduronic acid. Ulvan has a similar structure to glycosaminoglycans (GAGs) in mammals including chondroitin sulfate, dermatan sulfate, and heparan sulfate that has broad range applications for many years. Here, we provide an overview of ulvan based hydrogels for biomedical applications. Hydrogels are one of ulvan advances in polymer science for application in drug delivery, tissue engineering, and wound healing. This review presented an overview about functional information of ulvan based hydrogels and the promising potential in biomedicals collected from published papers in Scopus, PubMed, and Google Scholar. Other important aspects concerning properties, hydrogel-forming mechanisms, and ulvan based hydrogel developments were reported as well. As conclusion, ulvan showed interesting properties in forming hydrogels and promising advances in biomedical applications.
岩藻聚糖是一种从海洋绿藻中提取的天然硫酸化多糖，由 3-硫酸化鼠李半乳糖醛酸作为主要成分组成。它具有独特的化学结构，富含 L-鼠李糖、D-葡萄糖醛酸和 L-艾杜糖醛酸。岩藻聚糖的结构与哺乳动物中的糖胺聚糖（GAGs）相似，包括硫酸软骨素、硫酸皮肤素和硫酸乙酰肝素，多年来在许多领域都有广泛的应用。在这里，我们提供了基于岩藻聚糖的水凝胶在生物医学应用方面的概述。水凝胶是岩藻聚糖在聚合物科学方面的一项进展，可应用于药物输送、组织工程和伤口愈合。本综述从 Scopus、PubMed 和 Google Scholar 等出版物中收集了基于岩藻聚糖的水凝胶的功能信息和在生物医学方面的有前途的潜力，对其进行了概述。还报道了其他有关性质、水凝胶形成机制和基于岩藻聚糖的水凝胶发展的重要方面。总之，岩藻聚糖在形成水凝胶方面表现出有趣的性质，并在生物医学应用方面有很好的进展。
