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Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor.

作者信息

Zhang Honghui, Chen Tailai, Wu Keliang, Hou Zhenzhen, Zhao Shigang, Zhang Chuanxin, Gao Yuan, Gao Ming, Chen Zi-Jiang, Zhao Han

机构信息

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.

出版信息

Cell Res. 2021 Jul;31(7):814-817. doi: 10.1038/s41422-021-00507-8. Epub 2021 May 6.

DOI:10.1038/s41422-021-00507-8
PMID:33953335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8249641/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8249641/30a3bfa2a83a/41422_2021_507_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8249641/30a3bfa2a83a/41422_2021_507_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cf/8249641/30a3bfa2a83a/41422_2021_507_Fig1_HTML.jpg

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