Institute of Animal Physiology, Centre of Biosciences, Slovak Academy of Sciences, Šoltésovej 4, 040 00 Košice, Slovakia.
Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University, 12000 Prague, Czech Republic.
Int J Mol Sci. 2023 Apr 5;24(7):6778. doi: 10.3390/ijms24076778.
After fertilization, remodeling of the oocyte and sperm genome is essential for the successful initiation of mitotic activity in the fertilized oocyte and subsequent proliferative activity of the early embryo. Despite the fact that the molecular mechanisms of cell cycle control in early mammalian embryos are in principle comparable to those in somatic cells, there are differences resulting from the specific nature of the gene totipotency of the blastomeres of early cleavage embryos. In this review, we focus on the Chk1 kinase as a key transduction factor in monitoring the integrity of DNA molecules during early embryogenesis.
受精后，卵母细胞和精子基因组的重编程对于受精卵中有丝分裂活动的成功启动和早期胚胎的后续增殖活性至关重要。尽管早期哺乳动物胚胎中细胞周期控制的分子机制在原则上与体细胞中的机制相当，但由于早期分裂胚胎的卵裂球的基因全能性的特定性质，存在差异。在这篇综述中，我们重点介绍 Chk1 激酶作为在早期胚胎发生过程中监测 DNA 分子完整性的关键转导因子。
