Abdelnabi Mahmoud, Eshak Nouran, Almaghraby Abdallah, Saleh Yehia, Gerges Fady, Ahmed Ashraf
Cardiology and Angiology Unit, Department of Clinical and Experimental Internal Medicine, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas.
Proc (Bayl Univ Med Cent). 2021 Feb 5;34(3):361-363. doi: 10.1080/08998280.2021.1874774.
End-stage renal disease (ESRD) is considered an independent risk factor of cardiovascular and cerebrovascular events. This review highlights atherosclerotic risk, lipid metabolism alterations, and four studies on the use of statins in ESRD-two of which showed a statistically significant effect of statins on the primary endpoints and two of which did not. Since effects were seen with higher doses of statins, further research is needed on the protective effects of intermediate to higher doses of statins in ESRD patients.
终末期肾病（ESRD）被认为是心脑血管事件的独立危险因素。本综述重点介绍了动脉粥样硬化风险、脂质代谢改变，以及四项关于他汀类药物在终末期肾病中应用的研究——其中两项研究显示他汀类药物对主要终点有统计学显著效果，另外两项则未显示出该效果。由于较高剂量的他汀类药物显现出了效果，因此需要进一步研究中等至高剂量的他汀类药物对终末期肾病患者的保护作用。
