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本文引用的文献

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Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide.窄治疗指数药物:对氟卡尼的临床药理学考量
Eur J Clin Pharmacol. 2015 May;71(5):549-67. doi: 10.1007/s00228-015-1832-0. Epub 2015 Apr 15.
2
Flecainide toxicity--treatment with intravenous fat emulsion and extra corporeal life support.氟卡尼中毒——静脉输注脂肪乳剂及体外生命支持治疗
Acute Card Care. 2013 Dec;15(4):90-2. doi: 10.3109/17482941.2013.841949. Epub 2013 Nov 7.
3
A life-threatening flecainide overdose treated with intravenous fat emulsion.静脉注射脂肪乳剂治疗危及生命的氟卡尼过量中毒
Pacing Clin Electrophysiol. 2013 Mar;36(3):e87-9. doi: 10.1111/j.1540-8159.2012.03485.x. Epub 2012 Aug 8.
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Management of sodium-channel blocker poisoning: the role of hypertonic sodium salts.钠通道阻滞剂中毒的处理:高渗钠盐的作用。
Eur Rev Med Pharmacol Sci. 2010 Jan;14(1):25-30.
5
Flecainide cardiotoxicity precipitated by electrolyte imbalance. Caution with thiazide diuretics.电解质失衡引发的氟卡尼心脏毒性。使用噻嗪类利尿剂时需谨慎。
Emerg Med J. 2007 May;24(5):e26. doi: 10.1136/emj.2006.044362.
6
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.在不借助体外治疗的情况下处理严重氟卡尼过量导致的心血管衰竭。
Emerg Med Australas. 2007 Apr;19(2):155-9. doi: 10.1111/j.1742-6723.2006.00909.x.
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Drug therapy. Flecainide.药物治疗。氟卡尼。
N Engl J Med. 1986 Jul 3;315(1):36-41. doi: 10.1056/NEJM198607033150106.
8
Pharmacokinetics of flecainide acetate in patients with severe renal impairment.
Clin Pharmacol Ther. 1988 Apr;43(4):449-55. doi: 10.1038/clpt.1988.57.
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Clinical course and outcome in class IC antiarrhythmic overdose.I类C型抗心律失常药物过量的临床过程及转归
J Toxicol Clin Toxicol. 1990;28(4):433-44. doi: 10.3109/15563659009038586.
10
Long-term safety and efficacy of flecainide in the treatment of supraventricular tachyarrhythmias: the United States experience. The Flecainide Supraventricular Tachyarrhythmia Investigators.氟卡尼治疗室上性快速心律失常的长期安全性和有效性:美国的经验。氟卡尼室上性快速心律失常研究组。
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肝移植术后晚期氟卡尼中毒

Flecainide toxicity late after liver transplantation.

作者信息

Elsaid Ossama, Tecson Kristen M, Khan Hafiza, Assar Manish D

机构信息

Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.

Baylor Heart and Vascular Institute, Baylor Scott & White Research Institute, Dallas, Texas.

出版信息

Proc (Bayl Univ Med Cent). 2021 Jan 22;34(3):378-379. doi: 10.1080/08998280.2020.1871266.

DOI:10.1080/08998280.2020.1871266
PMID:33953467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8059910/
Abstract

Flecainide is an antiarrhythmic agent indicated for patients with supraventricular arrhythmias without ischemic or structural heart disease. Flecainide toxicity is a rare condition in which patients may present with bradycardia, widening of QRS, PR prolongation, ventricular tachycardia, syncope, malaise, dizziness, visual disturbance, nausea, vomiting, and/or lethargy. It carries an associated mortality rate of approximately 10%. Herein, we describe the course of a patient who experienced flecainide toxicity in the setting of renal and liver failure.

摘要

氟卡尼是一种抗心律失常药物,适用于无缺血性或结构性心脏病的室上性心律失常患者。氟卡尼中毒是一种罕见的情况,患者可能出现心动过缓、QRS波增宽、PR间期延长、室性心动过速、晕厥、不适、头晕、视觉障碍、恶心、呕吐和/或嗜睡。其相关死亡率约为10%。在此,我们描述了一名在肾衰竭和肝衰竭情况下发生氟卡尼中毒的患者的病程。