Xiu Lei, Yao Xiao-Ai, Jiang Tao
Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Apr 28;14:1823-1831. doi: 10.2147/DMSO.S299422. eCollection 2021.
Chinese adults with early-onset type 2 diabetes mellitus have impaired diastolic function. This study aims to analyse the association between serum vitamin D levels and cardiac diastolic dysfunction in Chinese adults with early-onset type 2 diabetes mellitus.
We enrolled Chinese adults with early-onset type 2 diabetes mellitus in this study. These patients were divided into two groups: those with diastolic dysfunction and those without diastolic dysfunction. We then compared the levels of serum 25-hydroxyvitamin D [25-(OH)D] between the two groups. The correlation between diastolic function and 25-(OH)D was evaluated by Pearson correlation analysis. Finally, binary logistic regression was used to analyse the relationship between the decrease in diastolic function and 25-(OH)D and other indexes in Chinese adults with early-onset type 2 diabetes mellitus.
The level of 25-(OH)D in patients with early-onset type 2 diabetes mellitus complicated with cardiac diastolic dysfunction was significantly lower than that in patients without cardiac diastolic dysfunction (P<0.01). The degree of liver fibrosis in adult patients with early-onset type 2 diabetes mellitus complicated with diastolic dysfunction was significantly higher than that in adult patients without diastolic dysfunction (P<0.01). Moreover, decreased 25-(OH)D levels were associated with decreased diastolic function in adults with early-onset type 2 diabetes.
25-(OH)-D was identified as an independent predictor of decreased diastolic function in adults with early-onset type 2 diabetes. The serum 25-(OH)D level in adults with early-onset type 2 diabetes was significantly reduced. 25-(OH)D influences the reduction in diastolic function in adults with early-onset type 2 diabetes and can be used as a predictor of decreased diastolic function in such patients.
早发型2型糖尿病的中国成年人存在舒张功能受损。本研究旨在分析早发型2型糖尿病的中国成年人血清维生素D水平与心脏舒张功能障碍之间的关联。
我们在本研究中纳入了早发型2型糖尿病的中国成年人。这些患者被分为两组：有舒张功能障碍的患者和无舒张功能障碍的患者。然后我们比较了两组之间血清25-羟维生素D[25-(OH)D]的水平。通过Pearson相关分析评估舒张功能与25-(OH)D之间的相关性。最后，采用二元逻辑回归分析早发型2型糖尿病的中国成年人舒张功能降低与25-(OH)D及其他指标之间的关系。
早发型2型糖尿病合并心脏舒张功能障碍患者的25-(OH)D水平显著低于无心脏舒张功能障碍的患者(P<0.01)。早发型2型糖尿病合并舒张功能障碍的成年患者肝纤维化程度显著高于无舒张功能障碍的成年患者(P<0.01)。此外，早发型2型糖尿病成年人中25-(OH)D水平降低与舒张功能降低相关。
25-(OH)-D被确定为早发型2型糖尿病成年人舒张功能降低的独立预测因子。早发型2型糖尿病成年人的血清25-(OH)D水平显著降低。25-(OH)D影响早发型2型糖尿病成年人舒张功能的降低，可作为此类患者舒张功能降低的预测指标。
