多囊卵巢综合征患者卵巢颗粒细胞中 miR-188-3p 的增加。
Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome.
机构信息
Department of Ultrasound, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai 200011, China.
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.
出版信息
Comput Math Methods Med. 2021 Apr 15;2021:5587412. doi: 10.1155/2021/5587412. eCollection 2021.
MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated that miR-188-3p might have a rare function of upregulating its targeted expression. This discovery will increase our understanding of the pathology of PCOS and provide new targets for treatment strategies.
microRNA 靶标网络在疾病中经常失调。我们的目的是研究多囊卵巢综合征（PCOS）的这种失调。通过对公共 RNAseq 数据集的生物信息学重新分析，我们发现 miR-188-3p 是诱导率最高的 miRNA，并表明 miR-188-3p 可能具有上调其靶基因表达的罕见功能。这一发现将增进我们对 PCOS 病理学的理解，并为治疗策略提供新的靶标。
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