Akre Shivani, Sharma Kapil, Chakole Swarupa, Wanjari Mayur B
Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2022 Aug 4;14(8):e27689. doi: 10.7759/cureus.27689. eCollection 2022 Aug.
Polycystic ovarian syndrome (PCOS) is an endocrine disorder. This condition is characterized by chronic anovulation and ovarian dysfunction, unlike other ovulation disorders when the ovaries are non-functional or abnormal. Currently, most therapy is centred on the patient's primary complaint. Treatment focuses on reducing hyperandrogenism symptoms, restoring menstrual regularity, and achieving conception. In treating infertility caused by polycystic ovarian syndrome, letrozole (an aromatase inhibitor) appears to be more successful than clomiphene citrate (an anti-estrogen and a reference infertility drug). When provided by a multidisciplinary team, it can help patients maintain appropriate lifestyle changes, such as reducing body fat, increasing metabolism, and enhancing reproductive health. Compound oral contraceptives are the most common kind of androgen inhibitor and are the preferred therapy for menstrual disruption in PCOS patients who do not want to get pregnant. Weight loss should be prioritized for women with PCOS since a healthy, balanced diet combined with regular exercise can boost metabolism, increase insulin sensitivity, and aid weight loss safely. This will improve their physical health. Other than reproductive symptoms, PCOS symptoms include insulin resistance (IR), metabolic syndrome (MS), and chronic low-grade inflammation. Our understanding of the pathophysiological process, diagnosis, and therapy of PCOS has advanced recently.
多囊卵巢综合征(PCOS)是一种内分泌紊乱疾病。与其他卵巢无功能或异常的排卵障碍不同,这种病症的特征是慢性无排卵和卵巢功能障碍。目前,大多数治疗以患者的主要诉求为中心。治疗重点在于减轻高雄激素血症症状、恢复月经规律以及实现受孕。在治疗由多囊卵巢综合征引起的不孕症方面,来曲唑(一种芳香化酶抑制剂)似乎比枸橼酸氯米芬(一种抗雌激素药物及不孕症参考药物)更为有效。由多学科团队提供治疗时,可帮助患者维持适当的生活方式改变,如减少体脂、提高新陈代谢以及增强生殖健康。复方口服避孕药是最常见的雄激素抑制剂类型,是不想怀孕的多囊卵巢综合征患者月经紊乱的首选治疗方法。多囊卵巢综合征女性应优先考虑减重,因为健康、均衡的饮食结合规律运动可促进新陈代谢、提高胰岛素敏感性并安全辅助减重。这将改善她们的身体健康。除生殖症状外,多囊卵巢综合征的症状还包括胰岛素抵抗(IR)、代谢综合征(MS)和慢性低度炎症。我们对多囊卵巢综合征的病理生理过程、诊断和治疗的认识最近有了进展。