Odo Rita Ifeoma, Uchendu Chukwuka Nwocha, Okeke Somtoo Ethelbert
Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.
Vet Res Forum. 2021 Winter;12(1):7-13. doi: 10.30466/vrf.2020.104327.2480. Epub 2021 Mar 15.
The study was done to ascertain the protective potentials of ethanol seed extract of on aluminum chloride-induced reproductive and hematological toxicities. Thirty mature male rats were used for the study. They were assigned into five groups (n = 6). Group 1 was treated daily with aluminum chloride (100 mg kg) for 8 weeks. Group 2 was treated with aluminum chloride (100 mg kg) and seed extract (CLSE) 200 mg kg simultaneously for 8 weeks. Group 3 was served as a normal control and given distilled water as a placebo daily for 8 weeks. Group 4 was only treated with CLSE (200 mg kg) for eight weeks. Group 5 was only treated with aluminum chloride (100 mg kg) for 8 weeks and then treated with CLSE (200 mg kg) for another 4 weeks. Testosterone level, testicular weight, sperm motility, gonadal sperm, and extragonadal sperm reserves showed significant increases in group 2 compared to groups 1 and 5. Optimum histoarchitectural protection of the seminiferous tubules was observed in group 2, which did not differ from normal ones. For the hematological parameters, optimum protection was also observed in group 2 compared to other groups. From the results, ethanol seed extract of demonstrated protective potentials against aluminum's harmful effects on the male reproductive system and hematology in an experimental male rat model.
本研究旨在确定[植物名称]乙醇种子提取物对氯化铝诱导的生殖和血液毒性的保护潜力。本研究使用了30只成年雄性大鼠。它们被分为五组（n = 6）。第1组每天用氯化铝（100毫克/千克）处理8周。第2组同时用氯化铝（100毫克/千克）和[植物名称]种子提取物（CLSE，200毫克/千克）处理8周。第3组作为正常对照组，每天给予蒸馏水作为安慰剂，持续8周。第4组仅用CLSE（200毫克/千克）处理8周。第5组仅用氯化铝（100毫克/千克）处理8周，然后用CLSE（200毫克/千克）再处理4周。与第1组和第5组相比，第2组的睾酮水平、睾丸重量、精子活力、性腺精子和性腺外精子储备显著增加。在第2组中观察到生精小管的最佳组织架构保护，与正常组无差异。对于血液学参数，与其他组相比，第2组也观察到了最佳保护。从结果来看，[植物名称]乙醇种子提取物在实验性雄性大鼠模型中显示出对铝对雄性生殖系统和血液学有害影响的保护潜力。
