Engelhard Yechiel N, Gazer Benny, Paran Esther
Hypertension Unit, Faculty of Health Sciences, Soroka University Medical Centre, Ben Gurion, University of the Negev, 84101 Beer Sheva, Israel.
Am Heart J. 2006 Jan;151(1):100. doi: 10.1016/j.ahj.2005.05.008.
Treatment of hypertension (HT) can reduce the risk for cardiovascular diseases. Tomato extract contains carotenoids such as lycopene, beta carotene, and vitamin E, which are known as effective antioxidants, to inactivate free radicals, and to slow the progression of atherosclerosis. The purpose of our study was to evaluate the effect of tomato extract on systolic and diastolic blood pressure in grade-1 HT, on serum lipoproteins, plasma homocysteine, and oxidative stress markers.
This study is a single-blind, placebo-controlled trial. Thirty-one subject with grade-1 HT, without concomitant diseases, who required no antihypertensive or lipid-lowering drug therapy, who were recruited from primary care clinics, completed the trial. Subjects entered a 4-week placebo period, then an 8-week treatment period with tomato extract, 250 mg Lyc-O-Mato, and a 4-week control period with placebo.
Systolic blood pressure decreased from 144 (SE +/- 1.1) to 134 mm Hg (SE +/- 2, P < .001), and diastolic blood pressure decreased from 87.4 (SE +/- 1.2) to 83.4 mm Hg (SE +/- 1.2, P < .05). No changes in blood pressure were demonstrated during placebo periods. Thiobarbituric acid-reactive substances, a lipid peroxidation products marker, decreased from 4.58 (SE +/- 0.27) to 3.81 nmol/mg (SE +/- 0.32, P < .05). No significant changes were found in lipid parameters.
A short-term treatment with antioxidant-rich tomato extract can reduce blood pressure in patients with grade-1 HT, naive to drug therapy. The continuous effect of this treatment and the long-term beneficial effect on cardiovascular risk factors still need to be demonstrated.
高血压（HT）治疗可降低心血管疾病风险。番茄提取物含有类胡萝卜素，如番茄红素、β-胡萝卜素和维生素E，这些物质是已知的有效抗氧化剂，可使自由基失活，并减缓动脉粥样硬化的进展。我们研究的目的是评估番茄提取物对1级高血压患者收缩压和舒张压、血清脂蛋白、血浆同型半胱氨酸及氧化应激标志物的影响。
本研究是一项单盲、安慰剂对照试验。从基层医疗诊所招募了31名无合并症的1级高血压患者，他们无需抗高血压或降脂药物治疗，完成了该试验。受试者先进入为期4周的安慰剂期，然后进入为期8周的番茄提取物（250mg Lyc-O-Mato）治疗期，最后进入为期4周的安慰剂对照期。
收缩压从144（标准误±1.1）降至134mmHg（标准误±2，P<.001），舒张压从87.4（标准误±1.2）降至83.4mmHg（标准误±1.2，P<.05）。在安慰剂期血压无变化。脂质过氧化产物标志物硫代巴比妥酸反应性物质从4.58（标准误±0.27）降至3.81nmol/mg（标准误±0.32，P<.05）。脂质参数未发现显著变化。
富含抗氧化剂的番茄提取物短期治疗可降低未接受药物治疗的1级高血压患者的血压。这种治疗的持续效果以及对心血管危险因素的长期有益作用仍需进一步证实。
