Koivisto P V, Miettinen T A
Second Dept. of Medicine, University of Helsinki, Finland.
Scand J Gastroenterol. 1988 May;23(4):422-6. doi: 10.3109/00365528809093889.
The human bile contains several noncholesterol sterols, of which the cholesterol precursor sterols are quantitatively the most important. Detailed data on factors that regulate the amount of these sterols in the bile have not been available. In this study the effect of chronic stimulation of cholesterol synthesis on biliary cholesterol precursor sterol content was evaluated by measuring these sterols in the bile and plasma of familial hypercholesterolemia patients with and without ileal exclusion. In the operated patients cholesterol synthesis was fivefold increased, and cholesterol precursor sterols comprised 7% of the biliary sterols, compared with 2% in the control patients. All eight biliary cholesterol precursor sterols measured were significantly increased in the operated patients, and the increase was similar to that of respective sterols in plasma. Hence, the biliary methyl sterols were increased 2 to 4 times, the lathosterols 5 times, but demosterol only 1.5 times. The proportion of lathosterol was higher and that of lanosterol lower in the bile of the operated than in that of the control patients. We conclude that activation of cholesterol synthesis increases the amount of cholesterol precursor sterols in the bile in proportion to the increase of these sterols in plasma and to the overall cholesterol synthesis.
人胆汁含有几种非胆固醇甾醇，其中胆固醇前体甾醇在数量上最为重要。关于调节胆汁中这些甾醇含量的因素，尚无详细数据。在本研究中，通过测量家族性高胆固醇血症患者（有或无回肠排除术）胆汁和血浆中的这些甾醇，评估了胆固醇合成的慢性刺激对胆汁中胆固醇前体甾醇含量的影响。在接受手术的患者中，胆固醇合成增加了五倍，胆固醇前体甾醇占胆汁甾醇的7%，而对照患者为2%。在接受手术的患者中，所测量的所有八种胆汁胆固醇前体甾醇均显著增加，且增加幅度与血浆中相应甾醇的增加幅度相似。因此，胆汁甲基甾醇增加了2至4倍，羊毛甾醇增加了5倍，但胆甾烯醇仅增加了1.5倍。与对照患者相比，接受手术患者胆汁中羊毛甾醇的比例更高，而羊毛脂甾醇的比例更低。我们得出结论，胆固醇合成的激活会使胆汁中胆固醇前体甾醇的含量与血浆中这些甾醇的增加以及整体胆固醇合成的增加成比例增加。
