School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Chem Commun (Camb). 2021 Jun 1;57(44):5466-5469. doi: 10.1039/d0cc08008j.
The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.
本文报道了未经保护的 DNA 大分子单体的直接、接枝、开环复分解聚合（ROMP）。通过调整聚合条件，可以实现良好的控制，从而快速高效地合成含 DNA 的梳状嵌段共聚物，而无需保护 DNA 碱基。
