Busnach G, Cappelleri A, Vaccarino V, Franceschini G, Dal Col A, Perrino M L, Brando B, Sirtori C, Minetti L
Divisione di Nefrologia, Ospedale Cà Granda, Milano, Italia.
Blood Purif. 1988;6(3):156-61. doi: 10.1159/000169540.
Seven patients with familial hypercholesterolemia were treated fortnightly for 3 months by selective low-density lipoprotein apheresis with dextran-sulfate cellulose column (DSC). Subsequently, 4 of them were treated with semiselective double filtration. No cholesterol-lowering drugs were given. Plasma processed ranged from 39 to 58 ml/kg body weight/procedure. Fractional removals from plasma filtrate at the secondary treatment (adsorption or fractionation) for total cholesterol, high-density lipoprotein cholesterol, and albumin, respectively, were 0.84, 0.06, and 0.03 with DSC and 0.74, 0.47 and 0.35 with double filtration. Postapheresis reductions of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were 57, 15, and 59% with DSC and 47,35, and 48% with double filtration. Both methods are suitable for clinical use, but with a 15-day treatment schedule, lowering circulating lipid fraction levels are maintained with DSC.
7例家族性高胆固醇血症患者每两周接受1次选择性低密度脂蛋白分离治疗，使用硫酸葡聚糖纤维素柱（DSC），持续3个月。随后，其中4例接受半选择性双重过滤治疗。未给予降胆固醇药物。每次治疗处理的血浆量为39至58毫升/千克体重。二次治疗（吸附或分级分离）时，血浆滤液中总胆固醇、高密度脂蛋白胆固醇和白蛋白的分离率，使用DSC时分别为0.84、0.06和0.03，使用双重过滤时分别为0.74、0.47和0.35。治疗后总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的降低率，使用DSC时分别为57%、15%和59%，使用双重过滤时分别为47%、35%和48%。两种方法均适用于临床应用，但采用15天的治疗方案时，DSC能维持循环脂质组分水平的降低。
