Department of Neurosurgery, Dongyang People's Hospital, 60 West Wuning Road, Jinhua, 322100, Zhejiang, China.
Biol Trace Elem Res. 2022 Mar;200(3):1089-1094. doi: 10.1007/s12011-021-02742-x. Epub 2021 May 5.
Copper as an essential trace element is hypothesized to be involved in stroke risk. However, the evidence for associations between copper and stroke risk factors such as lipid levels has been mixed. This study aimed to examine the relationships between serum copper and lipid levels among 3425 participants aged 20 years and older from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Data on administered questionnaires, serum copper concentrations, and lipid levels (total cholesterol, HDL cholesterol, triglycerides, and LDL cholesterol) were used. Associations between serum copper and lipid levels were evaluated using both multivariable linear regression and logistic regression models. In the linear regression models, total cholesterol and LDL cholesterol levels increased with increasing copper concentrations among women. Each 1 unit (μg/dL) increase in serum copper concentrations was associated with roughly 0.11 mg/dL higher total cholesterol (95%CI: 0.04-0.18; P < 0.05) and roughly 0.09 mg/dL higher LDL cholesterol (95%CI: 0.01-0.17; P < 0.05) among women, respectively. Serum copper was positively associated with high LDL cholesterol among women, and the multivariate-adjusted OR (95% CI) for the third quartile of serum copper concentrations was 4.25 (1.15-15.77) compared with the lowest quartile. Moreover, compared with the lowest quartile, the multivariate-adjusted OR (95% CI) for the third quartile of serum copper concentrations was 1.82 (1.16-2.85) for risk of having high total cholesterol among men. No significant association between serum copper and triglycerides levels was observed. These findings suggest that copper may impact stroke health via effects on lipid levels but need to be confirmed with prospective data.
铜作为一种必需的微量元素，据推测与中风风险有关。然而，铜与血脂水平等中风风险因素之间的关联证据尚不一致。本研究旨在检验 2011-2016 年全国健康与营养调查（NHANES）中 3425 名 20 岁及以上参与者血清铜与血脂水平之间的关系。使用了问卷调查、血清铜浓度和血脂水平（总胆固醇、高密度脂蛋白胆固醇、甘油三酯和低密度脂蛋白胆固醇）的数据。使用多元线性回归和逻辑回归模型评估了血清铜与血脂水平之间的关系。在线性回归模型中，女性血清铜浓度与总胆固醇和 LDL 胆固醇水平呈正相关。血清铜浓度每增加 1 个单位（μg/dL），总胆固醇约增加 0.11mg/dL（95%CI：0.04-0.18；P<0.05），LDL 胆固醇约增加 0.09mg/dL（95%CI：0.01-0.17；P<0.05）。血清铜与女性高 LDL 胆固醇呈正相关，与血清铜浓度最低四分位数相比，第三四分位数的多变量校正比值比（95%CI）为 4.25（1.15-15.77）。此外，与血清铜浓度最低四分位数相比，第三四分位数的多变量校正比值比（95%CI）为 1.82（1.16-2.85），男性高总胆固醇的风险增加。血清铜与甘油三酯水平之间没有显著关联。这些发现表明，铜可能通过影响血脂水平对中风健康产生影响，但需要前瞻性数据加以证实。
