血液环氧乙烷、全身炎症与血清脂质谱：来自 NHANES 2013-2016 的结果。
Blood ethylene oxide, systemic inflammation, and serum lipid profiles: Results from NHANES 2013-2016.
机构信息
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China; Department of Cardiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215002, China.
出版信息
Chemosphere. 2022 Jul;299:134336. doi: 10.1016/j.chemosphere.2022.134336. Epub 2022 Mar 22.
BACKGROUND
Using data from the National Health and Nutrition Examination Survey (NHANES), this study aimed to explore the relationship between ethylene oxide (EO) exposure and serum lipid profiles as well as the mediation effect of systemic inflammation among the general adult population.
METHODS
This cross-sectional study analyzed NHANES data from 2013 to 2016, examining a total of 2721 participants. The EO biomarker (hemoglobin adduct of EO [HbEO]) was quantified in blood using a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The association among HbEO levels, inflammatory biomarkers, and four serum lipids was evaluated using a multivariable linear regression model. Mediating analysis was performed to examine the effect of inflammatory biomarkers on the relationship between HbEO levels and serum lipid profiles.
RESULTS
As the quartiles of HbEO increased, high-density lipoprotein cholesterol (HDL-C) monotonically decreased (p for trend <0.001). Using the lowest quartile of HbEO as a reference, the percent change for HDL-C was 6.30% (95% CI: 3.89%, 8.71%) in the highest quartile of HbEO. HbEO levels were dose-dependently associated with triglycerides (TG) (p for trend = 0.001). The percent change in TG in the fourth quartile of HbEO was 17.24% (95% CI: 2.01%, 32.48%) compared to the first quartile. Overall, inflammatory biomarkers (hs-CRP, alkaline phosphatase, white blood cell count, neutrophil count, and lymphocyte count) increased monotonically in correlation with increasing HbEO levels (all p for trend <0.01); were positively correlated with total cholesterol (TC), TG, and low-density lipoprotein cholesterol (LDL-C); and were negatively associated with HDL-C. Additionally, inflammatory biomarkers strongly mediated the relationships between HbEO and HDL-C and TG with maximum mediated proportions of 21.40% and 33.40%, respectively.
CONCLUSIONS
These findings suggest that HbEO is closely linked to serum lipid profiles and that systemic inflammation may be a key mediator of this association.
背景
本研究利用来自国家健康和营养检查调查（NHANES）的数据，旨在探讨一般成年人群中环氧乙烷（EO）暴露与血清脂质谱之间的关系，以及全身炎症在此关系中的中介作用。
方法
本横断面研究分析了 2013 年至 2016 年 NHANES 数据，共纳入 2721 名参与者。采用高效液相色谱-串联质谱法（HPLC-MS/MS）检测血液中的 EO 生物标志物（EO 血红蛋白加合物 [HbEO]）。采用多变量线性回归模型评估 HbEO 水平与炎症标志物和四种血清脂质之间的关联。进行中介分析以评估炎症标志物对 HbEO 水平与血清脂质谱之间关系的影响。
结果
随着 HbEO 四分位间距的增加，高密度脂蛋白胆固醇（HDL-C）呈单调下降趋势（趋势检验 P<0.001）。以 HbEO 最低四分位间距为参照，HbEO 最高四分位间距的 HDL-C 百分比变化为 6.30%（95%可信区间：3.89%，8.71%）。HbEO 水平与甘油三酯（TG）呈剂量依赖性相关（趋势检验 P=0.001）。与第一四分位间距相比，HbEO 第四四分位间距的 TG 百分比变化为 17.24%（95%可信区间：2.01%，32.48%）。总体而言，炎症标志物（hs-CRP、碱性磷酸酶、白细胞计数、中性粒细胞计数和淋巴细胞计数）随 HbEO 水平的升高呈单调递增趋势（趋势检验 P<0.01）；与总胆固醇（TC）、TG 和低密度脂蛋白胆固醇（LDL-C）呈正相关；与 HDL-C 呈负相关。此外，炎症标志物强烈介导了 HbEO 与 HDL-C 和 TG 之间的关系，最大中介比例分别为 21.40%和 33.40%。
结论
这些发现表明，HbEO 与血清脂质谱密切相关，全身炎症可能是这种关联的关键中介因素。
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