Rahimi Ahmad Mustafa, Nabavizadeh Fatemeh, Ashabi Ghorbangol, Halimi Shahnaz, Rahimpour Milad, Vahedian Jalal, Panahi Mahshid
Department of Physiology, Medical school, Tehran University of Medical Sciences, Tehran, Iran.
Electrophysiology Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Nutr Cancer. 2021;73(10):2089-2099. doi: 10.1080/01635581.2020.1832237. Epub 2020 Oct 14.
The gastric cancer (GC) is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Herein, we studied the effects of probiotics () on subcutaneous implantation of xenograft GC. Moreover, the effect of probiotics () was compared with the capecitabine drug as known used drug against GC. Human GC tissue was obtained from patients with gastric adenocarcinoma and grafted into mice armpit. Probiotic () was given to animals by gavage 2 weeks prior to GC and 4 weeks after GC induction. Also, capecitabine was orally added through feeding tube at the last week of treatment procedure. All grafted animals received cyclosporine a day before the surgery and during the study period to prevent graft rejection. Capecitabine-probiotic complex reduced the size of the axillary implanted GC when compared with control group. Furthermore, combination of capecitabine and probiotic increased apoptotic and necrotic responses in the grafted tumor, blood cells (red blood cells, white blood cells, and platelet counts) in comparison with capecitabine. Probiotic () administration effectively improved the therapeutic index and outcomes, and also, improved the therapeutic effects of the capecitabine.
胃癌（GC）在生物学和遗传学上具有异质性，其分子水平的致癌机制尚不清楚。在此，我们研究了益生菌（）对异种移植GC皮下植入的影响。此外，将益生菌（）的效果与已知用于治疗GC的卡培他滨药物进行了比较。从胃腺癌患者获取人GC组织并移植到小鼠腋窝。在GC诱导前2周和诱导后4周通过灌胃给动物施用益生菌（）。此外，在治疗程序的最后一周通过饲管口服添加卡培他滨。所有移植动物在手术前一天和研究期间接受环孢素以防止移植排斥。与对照组相比，卡培他滨 - 益生菌复合物减小了腋窝植入GC的大小。此外，与卡培他滨相比，卡培他滨和益生菌的组合增加了移植肿瘤中的凋亡和坏死反应以及血细胞（红细胞、白细胞和血小板计数）。施用益生菌（）有效提高了治疗指数和疗效，并且还改善了卡培他滨的治疗效果。
