Alfonso E, Arrellanes L, Boruchoff S A, Ormerod L D, Albert D M
Cornea Service, Massachusetts Eye and Ear Infirmary, Boston.
Br J Ophthalmol. 1988 May;72(5):338-43. doi: 10.1136/bjo.72.5.338.
A 52-year-old Mexican man presented with asymptomatic, bilaterally symmetrical lipid infiltrates of the cornea and adjacent limbus. No evidence of previous ocular disease or systemic disorder of lipid metabolism could be detected. Penetrating keratoplasty of the right eye was required. The cornea was rigid and thick, with posterior bulging into the anterior chamber. Light microscopy revealed deep corneal lipid granules, foamy histiocytes, vascularisation, and chronic non-granulomatous inflammation. Transmission electron microscopy showed extracellular lipid spaces and numerous intracytoplasmic lipid vacuoles in histiocytes, keratocytes, conjunctival epithelium, and the endothelium of blood vessels in the corneal stroma and adjacent limbal conjunctiva. Histochemical analysis revealed the presence of neutral fats, free fatty acids, cholesterol, and phospholipids.
一名52岁的墨西哥男子出现角膜及相邻角膜缘双侧对称性脂质浸润，无症状。未发现既往眼部疾病或脂质代谢系统性疾病的证据。右眼需要进行穿透性角膜移植术。角膜坚硬且增厚，向后膨隆进入前房。光学显微镜检查显示角膜深层有脂质颗粒、泡沫状组织细胞、血管化及慢性非肉芽肿性炎症。透射电子显微镜检查显示在角膜基质和相邻角膜缘结膜的组织细胞、角膜细胞、结膜上皮及血管内皮细胞中有细胞外脂质间隙和大量胞质内脂质空泡。组织化学分析显示存在中性脂肪、游离脂肪酸、胆固醇和磷脂。
