Department of Child Psychiatry, Queen Fabiola Children's University Hospital (H.U.D.E.R.F.), Free University of Brussels, Avenue Jean-Joseph Crocq 15, 1020, Brussels, Belgium.
Department of Psychiatry and Sleep Laboratory, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium.
Psychiatr Q. 2021 Dec;92(4):1473-1488. doi: 10.1007/s11126-021-09922-x. Epub 2021 May 6.
Given the limited data currently available in the literature, the aim of this study was to investigate the risk of excessive daytime sleepiness (EDS) associated with major depression in a large sample of adolescents. The clinical and polysomnographic data of 105 adolescents recruited from the database of the Erasme Hospital sleep laboratory were analysed. A score > 10 on the Epworth Sleepiness Scale was used as cut-off for the diagnosis of EDS. The status (remitted or current) and the severity (mild to moderate or severe) of major depressive episodes were determined based on the diagnostic criteria of the DSM-IV-TR during a systematic psychiatric assessment. Logistic regression analyses were performed to determine the risk of EDS associated with major depression in adolescents. The prevalence of EDS was 34.3% in our sample of adolescents. After adjusting for the main confounding factors associated with EDS, multivariate logistic regression analysis demonstrated that unlike mild to moderate major depression, remitted major depression and severe major depression were risk factors for EDS in adolescents. In our study, we have highlighted that in adolescents, the EDS could be both residual symptom and severity marker of major depression, which seems to justify a systematic psychiatric assessment in adolescents with EDS complaints in order to allow better management of this problem in this particular subpopulation.
鉴于目前文献中有限的数据，本研究旨在调查在大量青少年样本中，与重度抑郁症相关的日间过度嗜睡（EDS）风险。从 Erasme 医院睡眠实验室的数据库中招募了 105 名青少年的临床和多导睡眠图数据进行了分析。Epworth 嗜睡量表评分>10 用作 EDS 的诊断截止值。根据 DSM-IV-TR 的诊断标准，在系统的精神病学评估中确定了重度抑郁症发作的状态（缓解或当前）和严重程度（轻度至中度或重度）。进行逻辑回归分析以确定青少年重度抑郁症与 EDS 相关的风险。在我们的青少年样本中，EDS 的患病率为 34.3%。在调整了与 EDS 相关的主要混杂因素后，多变量逻辑回归分析表明，与轻度至中度重度抑郁症不同，缓解的重度抑郁症和重度重度抑郁症是青少年 EDS 的危险因素。在我们的研究中，我们强调了在青少年中，EDS 既可以是重度抑郁症的残留症状，也可以是严重程度的标志物，这似乎证明了在有 EDS 主诉的青少年中进行系统的精神病学评估是合理的，以便在这个特定的亚人群中更好地管理这个问题。
